Results 111 to 120 of about 177,345 (263)

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

Advanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen, Zhidong Liu, Yanhang Sun, Xiaojun Xu, Zhexiao Lan, Junhao Zhao, Peitao Xu, Guiwen Ye, Jinteng Li   +8 more
wiley   +1 more source

Retrospective analysis of single-center experience in ultrasound-guided puncture drainage for pediatric appendiceal abscess. [PDF]

Front Pediatr
Lv C, Wang Z, Zhang C, Wei X, Wang X.
europepmc   +1 more source

Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy

Advanced Science, EarlyView.
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang, Xiuying Jiang, Xi Sun, Hao Chen, Jianjun Jin, Xin'e Shi   +5 more
wiley   +1 more source

Design and kinematics analysis of prostate assisted puncture robotic arm mechanism

Jixie chuandong
ObjectiveAiming at the problems of narrow surgical environment, high demand for human-machine cooperation and the influence of electromagnetic system on positioning effect in prostate biopsy surgery, a prostate assisted puncture robotic arm was designed ...
HU Yanfang, WANG Haonan, CAI Lidong, QIAN Meichen, WU Xijuan, LIU Changcheng   +5 more
doaj  

Enhancing precision in percutaneous vertebroplasty: a study on patient-specific 3D-printed guides for osteoporotic vertebral compression fractures. [PDF]

Front Surg
Liang JW, Qiao LN, Jia YA, Xue L, Zhao MY, Wang F.   +5 more
europepmc   +1 more source

Puncture test of geomembrane on the ground

Geosynthetics Engineering Journal, 2000
IKEDA, H., IMAIZUMI, S., HISHIYA, J., MIYAJI, H., YOSHINAO, T.   +4 more
openaire   +2 more sources

Skin Puncture Test Response Is Not Altered By Season of Testing [PDF]

Journal of Allergy and Clinical Immunology, 2016
Suzanne Warford, D. Lew, C. Michael, J. Lieberman   +3 more
openaire   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Consistency of multiparametric MRI-guided transperineal prostate biopsy and Gleason score after radical prostatectomy: A retrospective observational study. [PDF]

Medicine (Baltimore)
Wu Y, Xu L.
europepmc   +1 more source