Results 121 to 130 of about 177,345 (263)

A Dual‐Channel Synergistic Ultrasensitive Biosensor for Tumor Liquid Biopsy

Advanced Science, EarlyView.
ABSTRACT Liquid biopsy technology, which detects circulating tumor DNA (ctDNA) in cerebrospinal fluid, plays a crucial role in the early diagnosis and precision treatment of gliomas. However, the intrinsically low abundance and rapid clearance of ctDNA pose substantial challenges for conventional analytical techniques, such as droplet digital PCR and ...
Yu Sun, Jing Zhang, Chenqing Liu, Jing Lou, Sihui Wang, Xiangtian Ji, Xiaofang Zhao, Shirui Xu, Jingyu Feng, Bin Liu, Chao Chang, Qinggang Ge, Jun Yang   +12 more
wiley   +1 more source

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source

Characterization of patients with isolated REM sleep behavior disorder and cerebrospinal fluid α-synuclein negativity. [PDF]

NPJ Parkinsons Dis
Farfán F, Mammana A, Maya G, Ticca A, Montini A, Magliocchetti F, Muñoz-Lopetegi A, Vittoriosi E, Serradell M, Mastrangelo A, Arqueros A, Mariño N, Niñerola-Baizán A, Perissinotti A, Gaig C, Parchi P, Iranzo A.   +16 more
europepmc   +1 more source

Synergistic Dual Slip‐Link Toughening of a Water‐Rich Double Network Hydrogel Combining Slide‐Ring and Highly Entangled Networks

Advanced Science, EarlyView.
Two distinct slip‐link mechanisms – the slide‐ring pulley effect and highly entangled chains – are combined in a water‐rich double network hydrogel, achieving synergistic toughening, near‐complete reversibility, and exceptional friction tear resistance at >$>$91 wt.% water.
Subhankar Mandal, Saleh Assadi, Aseem Milind Visal, Ignacio Lorente Montero, Franck J. Vernerey, Carson J. Bruns   +5 more
wiley   +1 more source

Transition to tenecteplase is associated with shorter door-to-puncture times: a retrospective study from the Lone Star Stroke consortium TNK registry. [PDF]

Front Neurol
Luo A, Bandela S, Gealogo-Brown G, Goldberg MP, Slusher A, Behrouz R, Jafarli A, Prasad S, Olson D, Denbow M, Gebreyohanns M, Techan A, Venkatasubba Rao CP, Anderson JA, Kimmel B, Ovalle A, Patterson M, Savitz SI, Cruz-Flores S, Warach S, Birnbaum L.   +20 more
europepmc   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source

Comparison of Arterial Puncture Skill Improvement Between Training with an Arterial Puncture Part-Task Trainer Simulator and Conventional Training in Fifth-Year Medical Students: A Pilot Study

Advances in Medical Education and Practice
Natsinee Athinartrattanapong, Parinda Chamchoi, Phanorn Chalermdamrichai, Panvilai Tangkulpanich, Chaiyaporn Yuksen, Chantarat Palee, Suteenun Seesuklom Department of Emergency Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University ...
Athinartrattanapong N, Chamchoi P, Chalermdamrichai P, Tangkulpanich P, Yuksen C, Palee C, Seesuklom S   +6 more
doaj  

Adjusting Training Task Difficulty to Enhance Skill Transfer in Venipuncture: Evidence from Video Analysis. [PDF]

Adv Med Educ Pract
Yang J, Yi M, Wu F, Hu M, Yao Q, Zhou H, Xiao Y, Zhang Y, Wu Y, Zheng B.   +9 more
europepmc   +1 more source

A Portable and Dual‐Button Microneedle Device Enables Intelligent Multimodal Laser Sensing

Advanced Science, EarlyView.
A portable and dual‐button microneedle device enables rapid interstitial fluid sampling. Coupled with multimodal laser sensing and AI‐assisted data processing, the platform enables simultaneous molecular and elemental analysis for minimally invasive and multiplexed health assessment toward point‐of‐care diagnostics.
Yuanchao Liu, Xiujuan Hu, Shengqun Shi, Bowen Li, Zhixing Ge, Yunchen Long, Chaochao Sun, Annan Chen, Bingbing Gao, Lianbo Guo, Condon Lau, Wei Luo, Chwee Teck Lim   +12 more
wiley   +1 more source

Factors Associated With Unintended Dural Puncture and Failed Neuraxial Anesthesia in Obstetric Anesthesia. [PDF]

Cureus
Vallejo MC, Lilly CL, Saracoglu A, Saracoglu KT, Acevedo Bonilla H, Paul MD, Yilmaz KC, Cain JG.   +7 more
europepmc   +1 more source