Results 161 to 170 of about 196,234 (256)
Freeform extended depth-of-focus intraocular lens for more robust performance against physiological variations. [PDF]
J Biomed OptCharlot J +3 more
europepmc +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
The Eyes as a Mirror of the Unconscious: What Pupil Dilation Reveals About Unconscious Analytic Thought in Insight Problem Solving. [PDF]
J IntellMacchi L +3 more
europepmc +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Pupillary dynamics during hands-off L2 driving and transitions of control under high cognitive load. [PDF]
PLoS OneGoodridge CM +11 more
europepmc +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Pupil size reveals the perceptual quality and effortless nature of synesthesia. [PDF]
ElifeStrauch C, Leenaars C, Rouw R.
europepmc +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Cholinergic‐related pupil activity reflects level of emotionality during motor performance
Pupil size covaries with the diffusion rate of the cholinergic and noradrenergic neurons throughout the brain, which are essential to arousal. Recent findings suggest that slow pupil fluctuations during locomotion are an index of sustained activity in ...
Onderdijk, Kelsey E.0001715376288020028181879760918280490000-0001-9992-762026BDC8DA-086D-11E8-A1A2-03F311A95AF2 +6 more
core