Results 91 to 100 of about 89,765 (308)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Engineering ProceedingsThe eye, in a dominant sense, can suffer disorders, such as myopia or nearsightedness, because of VDU radiation exposure. One symptom which is often caused by excessive use of VDU is eye strain.
Alun Sujjada +3 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Evaluation of Cholinergic Deficiency in Preclinical Alzheimer’s Disease Using Pupillometry
Journal of Ophthalmology, 2017 Cortical cholinergic deficiency is prominent in Alzheimer’s disease (AD), and published findings of diminished pupil flash response in AD suggest that this deficiency may extend to the visual cortical areas and anterior eye.
Shaun Frost +8 more
doaj +1 more source
Ukrainian Neurosurgical Journal, 2010 Brain concussion (BC) is characterized mainly by damage of subcortical brain structures (chiasma) and extrastrial zone of optic pathway, oculomotor nerve and afferent part of pupil pathway.
N. M. Moyseenko
doaj +1 more source
Review of the Additional Support for Learning Act: adding benefits for learners: a report by HMIE to Scottish Ministers, November 2010 [PDF]
, 2010 Review background: "In May 2009, the Minister for Children and Early Years, gave a commitment to Parliament to establish a working group to report on how the Education (Additional Support for Learning) (Scotland) Act 2004 (the Act) is affecting ...
core
The primary function of REM sleep [PDF]
, 2006 In this paper, the physiological features associated with the different stages of REM sleep and with what information processing researchers have called “effort” and “arousal” are compared.
Bernhard, Mr. Andrew E.
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Individual differences in belief updating and phasic arousal are related to psychosis proneness
Communications PsychologyMany decisions entail the updating of beliefs about the state of the environment by accumulating noisy sensory evidence. This form of probabilistic reasoning may go awry in psychosis.
Peter R. Murphy +5 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source