Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
WHY DO GAMERS PURCHASE VIRTUAL ITEMS IN MOBA GAMES?
This study explores and analyzes multiplayer online battle arena (MOBA) gamers’ motivation, experience and purchasing behavior in purchasing virtual items.
Andini Ginanti Tuzzahra +1 more
doaj +1 more source
PENGARUH BINTANG IKLAN, KEPRIBADIAN MEREK, DAN KARAKTERISTIK PRODUK TERHADAP INTENSI MEMBELI GARNIER LIGHT COMPLETE VERSI CHELSEA ISLAN (STUDI KASUS PADA MAHASISWI UNJ) [PDF]
Wafa Silmy Kaffah, 2017; The Influence Of Celebrity Endorser, Brand Personality, and Product Characteristics againts Purchase Intention, Jakarta: Marketing Concentration, Department of Management, Faculty of Economics, State University of Jakarta ...
KAFFAH, WAFA SILMY
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Min Wang, Lin-Lin Sun, Jun-Dong Hou School of Economics and Management, China University of Geosciences, Wuhan, People’s Republic of ChinaCorrespondence: Jun-Dong HouSchool of Economics and Management, China University of Geosciences, Wuhan, People&
Wang M, Sun LL, Hou JD
doaj
PENGARUH PERFORMANCE APLIKASI GOJEK TERHADAP CONSUMER PURCHASE INTENTION DENGAN ROLE OF BUYER PERCEPTION SEBAGAI VARIABEL MEDIASI [PDF]
ABSTRAKTujuan penelitian ini adalah untuk mengetahui pengaruh performance aplikasi online terhadap consumer purchase intention melalui role of buyer perception sebagai variabel mediasi.
Munir Fuadi
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Pengaruh Iklan Di Televisi, Kualitas Produk Dan Harga Terhadap Citra Merek Serta Implikasinya Pada Minat Pembelian (Survei Pada Calon Konsumen Susu Sgm Di Kota Malang) [PDF]
This study aims to analyze and explain the Influence of Advertising on Television, Product Quality and Price toward Brand Image and Its Implication on Purchase Intention.
Kumadji, S. (Srikandi) +2 more
core
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Brief vs. Comprehensive Descriptions in Measuring Intentions to Purchase [PDF]
In forecasting demand for expensive consumer goods, direct questioning of potential consumers about their future purchasing plans has had considerable predictive success [1, 2, 4].
JS Armstrong, Terry Overton
core

