Results 101 to 110 of about 1,148,210 (288)
FRANCHISING AS A BUSINESS CONCEPT - CHANCE FOR MANY IN SERBIA
Ekonomika Poljoprivrede (1979), 2013 The development of the franchise network as an alternative solution in comparison with the traditional opening of the organizational units allows our own expansion through enganging less money and risk-sharing with local entrepreneurs who are already ...
Alija Jašarević, Mile Ličina
doaj
Consumer shopping behavior: how much do consumers save? [PDF]
, 2009 This paper documents the potential and actual savings that consumers realize from four particular types of purchasing behavior: purchasing on sale; buying in bulk (at a lower per unit price); buying generic brands; and choosing outlets.
Griffith, R. +3 more
core +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
TÜKETİCİLERİN HAZIR GİYİM TERCİHLERİNDE MARKA, REKLAM ARACI, TUTUM VE SATINALMA KARAR VERME TARZLARI
Yüzüncü Yıl Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2018 Günümüz yoğun rekabet ortamında hazır giyim sektöründe faaliyette bulunan firmalar ürün pazarlamasını çok çeşitli reklam etkinlikleri ile yerine getirmektedirler.
İbrahim Durmuş, Fetullah Battal
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
MARKALI ÜRÜN İLE İLGİLİ TÜKETİCİ DÜŞÜNCELERİNİN BELİRLENMESİ ÜZERİNE BİR ARAŞTIRMA
Selçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2016 Pazarlama dünyasındaki yoğun rekabet ortamında tüketiciler, aynı ürün grubuna ait pek çok farklı marka arasında sürekli olarak tercih yapmak durumunda kalmaktadırlar.
Ebru Onurlubaş, Tuna Şener
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
FEBS Open Bio, EarlyView.We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan +6 more
wiley +1 more source