Results 81 to 90 of about 646,738 (309)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
FRANCHISING AS A BUSINESS CONCEPT - CHANCE FOR MANY IN SERBIA
Ekonomika Poljoprivrede (1979), 2013 The development of the franchise network as an alternative solution in comparison with the traditional opening of the organizational units allows our own expansion through enganging less money and risk-sharing with local entrepreneurs who are already ...
Alija Jašarević, Mile Ličina
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
TÜKETİCİLERİN HAZIR GİYİM TERCİHLERİNDE MARKA, REKLAM ARACI, TUTUM VE SATINALMA KARAR VERME TARZLARI
Yüzüncü Yıl Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2018 Günümüz yoğun rekabet ortamında hazır giyim sektöründe faaliyette bulunan firmalar ürün pazarlamasını çok çeşitli reklam etkinlikleri ile yerine getirmektedirler.
İbrahim Durmuş, Fetullah Battal
doaj
FEBS Open Bio, EarlyView.Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda +12 more
wiley +1 more source
MARKALI ÜRÜN İLE İLGİLİ TÜKETİCİ DÜŞÜNCELERİNİN BELİRLENMESİ ÜZERİNE BİR ARAŞTIRMA
Selçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2016 Pazarlama dünyasındaki yoğun rekabet ortamında tüketiciler, aynı ürün grubuna ait pek çok farklı marka arasında sürekli olarak tercih yapmak durumunda kalmaktadırlar.
Ebru Onurlubaş, Tuna Şener
doaj
FEBS Open Bio, EarlyView.We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa +2 more
wiley +1 more source