Results 71 to 80 of about 646,738 (309)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
A COMPARISON OF SUPPLIERS AND THEIR LEVELS WITHIN THE PURCHASING PROCESS [PDF]
Acta Logistica, 2015 Due to the effects of the global economic crisis, manufacturing companies have been forced to look for savings in all areas. Many manufacturing entities in recent years have not sufficiently optimized their purchasing processes.
Petr Besta +2 more
doaj
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
STRATEGIC PURCHASING IN A PROJECT- BASED COMPANY – TO CENTRALIZE OR DECENTRALIZE [PDF]
Acta Logistica, 2014 Organizations all lie on a spectrum, at one end of which are firms with complete centralization of purchasing, and at the other end are firms with complete decentralization.
Eva Donociková
doaj
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Cost management in metallurgical production
Metalurgija, 2012 Price changes in the global raw material markets significantly infl uence the economic characteristics of Czech metallurgical companies as well. This article illustrates the utilization of changeable market situation when purchasing of raw materials infl
K. Janovská +5 more
doaj
Gender Differences and Consumer Behavior of Millennials
Acta Economica et Turistica, 2017 Millennial generation is considered the largest and best educated and therefore presents challenges to marketers. This paper aims to examine the gender differences in consumer behaviour of students - generation y.
Kraljević Radojka, Filipović Zrinka
doaj +1 more source
Why Substantial Budget Reallocations Are Not and Should Not Be a Major Factor in Active Purchasing in Dutch Healthcare; Comment on “Measuring Active Purchasing in Healthcare: Analysing Reallocations of Funds Between Providers to Evaluate Purchasing Systems Performance in the Netherlands” [PDF]
International Journal of Health Policy and ManagementThis commentary discusses the study by Stadhouders et al, which analyzes budget reallocations among Dutch healthcare providers as a result of one form of active purchasing.
Fredo Schotanus
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Knowledge of UK Residents About Importing Puppies from EU Countries
AnimalsThe number of puppies imported to the United Kingdom (UK) from the European Union (EU) is increasing, as are concerns about the legality, welfare and potential disease risks associated with their trade. This study aimed to use an online survey to collect
Zoe Belshaw, Rowena M. A. Packer
doaj +1 more source