Results 71 to 80 of about 215,424 (291)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Cost management in metallurgical production
Metalurgija, 2012 Price changes in the global raw material markets significantly infl uence the economic characteristics of Czech metallurgical companies as well. This article illustrates the utilization of changeable market situation when purchasing of raw materials infl
K. Janovská +5 more
doaj
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
FRANCHISING AS A BUSINESS CONCEPT - CHANCE FOR MANY IN SERBIA
Ekonomika Poljoprivrede (1979), 2013 The development of the franchise network as an alternative solution in comparison with the traditional opening of the organizational units allows our own expansion through enganging less money and risk-sharing with local entrepreneurs who are already ...
Alija Jašarević, Mile Ličina
doaj
Purchasing in relation to purchasing logistics and purchasing marketing
Contemporary Economy, 2011 Purchasing is the management of the company’s external resources in such way that the supply of all goods and services which are necessary for running, maintaining and managing the company’s primary and support activities is secured at the most favourable conditions.
openaire +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
The role of procurement quality controls in procurement performance in the energy sector in Zimbabwe
Cogent Engineering, 2019 Procurement performance is a rapidly developing area of research. Many companies are trying to find tools for optimising procurement performance measures in response to turbulent business markets and for efficiently controlling their business activities.
Tinotenda Fredrick Munyimi
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source