Results 81 to 90 of about 215,424 (291)

MARKALI ÜRÜN İLE İLGİLİ TÜKETİCİ DÜŞÜNCELERİNİN BELİRLENMESİ ÜZERİNE BİR ARAŞTIRMA

open access: yesSelçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2016
Pazarlama dünyasındaki yoğun rekabet ortamında tüketiciler, aynı ürün grubuna ait pek çok farklı marka arasında sürekli olarak tercih yapmak durumunda kalmaktadırlar.
Ebru Onurlubaş, Tuna Şener
doaj  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

TÜKETİCİLERİN HAZIR GİYİM TERCİHLERİNDE MARKA, REKLAM ARACI, TUTUM VE SATINALMA KARAR VERME TARZLARI

open access: yesYüzüncü Yıl Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2018
Günümüz yoğun rekabet ortamında hazır giyim sektöründe faaliyette bulunan firmalar ürün pazarlamasını çok çeşitli reklam etkinlikleri ile yerine getirmektedirler.
İbrahim Durmuş, Fetullah Battal
doaj  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

The effective factors in the decision making component of purchase management of Medical Equipment in hospitals affiliated to Tehran University of Medical Sciences

open access: yesبیمارستان, 2020
Bachground: The use of optimal purchasing methods in the medical equipment sector, along with the implementation of state laws and regulations by the government, can serve as a way to move towards smart purchases. To be raised.
Azam Lari   +3 more
doaj  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

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