Results 21 to 30 of about 1,087,096 (228)
Influence of Internal Partition with an Opening on Purging Flow Rate of Wind-Induced Ventilation [PDF]
E3S Web of ConferencesThe importance of natural ventilation has become more recognized for energy saving. Given the contemporary architectural designs, the utilization of wind-induced single-sided ventilation has become a prevailing format.
Toyosawa Kota +7 more
doaj +1 more source
Goodness of fit tests in random coefficient regression models [PDF]
, 1994 Random coefficient regressions have been applied in a wide range of fields, from biology to economics, and constitute a common frame for several important statistical models.
Delicado, Pedro, Romo, Juan
core +1 more source
AnimalInbreeding depression (ID) is a well-documented phenomenon associated with reduced fitness and possible extinction. However, ID can be mitigated or even eliminated through the interplay of inbreeding and selection, a process known as purging.
I. Nagy +4 more
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
The Operating Procedure of the Device Enhancing the Wheel-Rail Adhesion
CommunicationsThe results of the analysis of sand application efficiency for improving wheel-rail adhesion are presented. An algorithm for the sandbox operation is substantiated, based on supplying sand under the wheels when their slip reaches a critical level ...
Yuriy Y. Osenin +2 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Data from: Estimation of genetic purging under competitive conditions
, 2016 Inbreeding depression for fitness traits is a key issue in evolutionary biology and conservation genetics. The magnitude of inbreeding depression, though, may critically depend on the efficiency of genetic purging, the elimination or recessive ...
García-Dorado, Aurora +3 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Ballou’s Ancestral Inbreeding Coefficient: Formulation and New Estimate with Higher Reliability
AnimalsInbreeding is unavoidable in small populations. However, the deleterious effects of inbreeding on fitness-related traits (inbreeding depression) may not be an inevitable phenomenon, since deleterious recessive alleles causing inbreeding depression might ...
Tetsuro Nomura
doaj +1 more source