Results 151 to 160 of about 2,474,651 (380)
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Linchuang shenzangbing zazhiObjective To explore the incidence and risk factors of protein-energy wasting （PEW） in patients on maintenance hemodialysis （MHD） and construct a visual risk predictive model and verify its predictive performance.
Ming-mei Ding +4 more
doaj +1 more source
STUDIES ON THE PURIFICATION OF POLIOMYELITIS VIRUS [PDF]
, 1942 Hubert S. Loring, C. E. Schwerdt
openalex +1 more source
Analytical methods for bacterial kinetics studies [PDF]
, 1971 Methods utilize mathematical equations and models and specialized computer techniques.
Edwards, V. E., Wilke, C. R.
core +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Covalent bonding of antibodies of polystyrene latex beads: A concept [PDF]
, 1972 Technique facilitates purification of vaccines and production of immunoadsorption columns exhibiting relatively long stability.
Smith, D. G., Tenoso, H. J.
core +1 more source
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
Social risk profiles and diabetic kidney disease: prevalence and mortality in US adults
BMC Public HealthBackground Diabetic kidney disease (DKD) is a severe and prevalent complication of diabetes. Social contexts have been increasingly recognized as critical factors in the escalation and ongoing management of chronic diseases, including DKD.
Zishan Lin +5 more
doaj +1 more source
Effect of chlorine purification on oxidation resistance of some mechanical carbons [PDF]
Oxidation experiments were conducted with some experimental and commercial mechanical carbons at 650 C in dry air flowing at 28 cc/sec (STP). In general, purification of these carbon-graphites with chlorine at 2800 C improved oxidation resistance ...
Allen, G. P., Wisander, D. W.
core +1 more source
Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner +6 more
wiley +1 more source