Results 121 to 130 of about 146,626 (295)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Caffeine and paracetamol co-purify with C-reactive protein from surgical patients
European Journal of Medical ResearchBackground Cell damage caused by surgical trauma leads to the release of intracellular adenosine triphosphate (ATP), which activates purinergic P2X7 receptors and induces the maturation and secretion of the pro-inflammatory cytokine interleukin-1β (IL-1β)
Christina Buschhaus +6 more
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Cost-benefit analysis of a method using diatomaceous earth to purify Tamm-Horsfall protein
BioTechniques, 2004 Jaideep Shenoi +5 more
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
, 2015 Notes and translations of the ritual performed to defeat infernal deities and to purify a house based on the tablet concordance KBo X 45 (inventory no. 244/p). Emmanuel Laroche translated this text as "Rituel aux divinités infernales : purification d'une
Gonnet-Bağana, Hatice
core +1 more source
Purification of Roof-Harvested Rainwater Using Progressive Freeze Concentration
Chemical Engineering TransactionsRainwater can serve as a safe and sustainable source of drinking water. One common way to harvest rainwater is through runoff from the roofs of buildings. Depending on the cleanliness and material of the roofs, this roof-harvested rainwater can have very
How Chee Yang +4 more
doaj
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
In recent decades, nucleic acid self-assemblies have emerged as popular nanomaterials due to their programmable and robust assembly, prescribed geometry, and versatile functionality.
Akshay Shah (2469283) +5 more
core +1 more source