Results 11 to 20 of about 12,753 (213)

Evaluating antitumor activity of Escherichia coli purine nucleoside phosphorylase against head and neck patient‐derived xenografts [PDF]

Cancer Reports, 2023
Background Purine nucleoside phosphorylase (PNP) gene transfer represents a promising approach to treatment of head and neck malignancies. We tested recombinant adenovirus already in phase I/II clinical testing and leading‐edge patient‐derived xenografts
Regina Rab, Annette Ehrhardt, Bhagelu R. Achyut, Disha Joshi, Melissa Gilbert‐Ross, Chunzi Huang, Katharine Floyd, Anton V. Borovjagin, William B. Parker, Eric J. Sorscher, Jeong S. Hong   +10 more
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The Characterization of the Purine Nucleoside Phosphorylase from Agaricus bisporus and Its Potential Application in Reducing Purine Content in Beer [PDF]

Journal of Fungi
Beer, the most popular alcoholic beverage, poses health risks for individuals with gout and hyperuricemia due to its high purine content. Herein, we identified a novel purine nucleoside phosphorylase (AbPNP) from the edible mushroom Agaricus bisporus and
Jun Liu, Jian Lu
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Cerebellar abnormalities in purine nucleoside phosphorylase deficient mice

Neurobiology of Disease, 2012
Inherited defects in purine nucleoside phosphorylase (PNP) cause severe T cell immunodeficiency and progressive neurological dysfunction, yet little is known about the effects of PNP deficiency on the brain.
Alireza Mansouri, Weixian Min, Christina J. Cole, Sheena A. Josselyn, Jeffrey Theodore Henderson, Matthijs van Eede, R. Mark Henkelman, Cameron Ackerley, Eyal Grunebaum, Chaim M. Roifman   +9 more
doaj   +3 more sources

Purine nucleoside phosphorylase inhibition ameliorates age-associated lower urinary tract dysfunctions [PDF]

JCI Insight, 2020
In the aging population, lower urinary tract (LUT) dysfunction is common and often leads to storage and voiding difficulties classified into overlapping symptom syndromes.
Lori A. Birder, Amanda Wolf-Johnston, Alan J. Wein, Fangzhou Cheng, Mara Grove-Sullivan, Anthony J. Kanai, Alan M. Watson, Donna Stoltz, Simon C. Watkins, Anne M. Robertson, Diane Newman, Roger R. Dmochowski, Edwin K. Jackson   +12 more
doaj   +2 more sources

Purine nucleoside phosphorylase as a target for the treatment of interstitial cystitis/bladder pain syndrome with and without Hunner lesions [PDF]

Scientific Reports
Chronic visceral pain disorders, such as interstitial cystitis/bladder pain syndrome (IC/BPS), are difficult to treat, and therapies are limited in number and efficacy.
Lori A. Birder, Amanda Wolf-Johnston, Vladimir Ritov, Joel N. H. Stern, Robert Moldwin, Hann-Chorng Kuo, Edwin K. Jackson   +6 more
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Partial Purine Nucleoside Phosphorylase Deficiency Helps Determine Minimal Activity Required for Immune and Neurological Development [PDF]

Frontiers in Immunology, 2020
Introduction: Complete or near complete absence of the purine nucleoside phosphorylase (PNP) enzyme causes a profound T cell immunodeficiency and neurological abnormalities that are often lethal in infancy and early childhood.
Eyal Grunebaum, Eyal Grunebaum, Nicholas Campbell, Matilde Leon-Ponte, Xiaobai Xu, Hugo Chapdelaine   +5 more
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Radical Dehalogenation and Purine Nucleoside Phosphorylase E. coli: How Does an Admixture of 2′,3′-Anhydroinosine Hinder 2-fluoro-cordycepin Synthesis [PDF]

Biomolecules, 2021
During the preparative synthesis of 2-fluorocordycepin from 2-fluoroadenosine and 3′-deoxyinosine catalyzed by E. coli purine nucleoside phosphorylase, a slowdown of the reaction and decrease of yield down to 5% were encountered.
Alexey L. Kayushin, Julia A. Tokunova, Ilja V. Fateev, Alexandra O. Arnautova, Maria Ya. Berzina, Alexander S. Paramonov, Olga I. Lutonina, Elena V. Dorofeeva, Konstantin V. Antonov, Roman S. Esipov, Igor A. Mikhailopulo, Anatoly I. Miroshnikov, Irina D. Konstantinova   +12 more
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Multistep loss of catalytic and ligand binding abilities of hexameric purine nucleoside phosphorylase [PDF]

Scientific Reports
It is commonly believed that enzymatic catalysis is such a complex process, that even a small change in any physicochemical property of the enzyme results in a complete loss of the catalytic and ligand-binding capacity of the molecule.
Marta Narczyk, Agnieszka Bzowska
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Immunodeficiency, motor delay, and hypouricemia caused by a novel mutation of purine nucleoside phosphorylase gene in an Indian infant [PDF]

Annals of Indian Academy of Neurology, 2019
We describe an 11-month-old boy who presented with recurrent respiratory infections from 6 months of age. His elder sister died at 10 months with severe septicemia and meningitis. The boy had a mild motor delay.
Nikit Shah, Lokesh Lingappa, Ramesh Konanki, Sirisha Rani, Ramprasad Vedam, Sakthivel Murugan   +5 more
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Cloning and expression of recombinant purine nucleoside phosphorylase in the methylotrophic yeast Pichia pastoris

Journal of Advanced Biotechnology and Experimental Therapeutics, 2023
Purine Nucleoside Phosphorylase (PNP) is an enzyme involved in biosynthetic pathway of purine nucleosides. Purine nucleoside phosphorylase catalyzes the cleavage of the glycosidic bond of ribo- or deoxyribonucleosides to form the purine base and ...
Jaloliddin Abdurakhmanov, Sobirdjan Sasmakov, Shukhrat Khasanov, Oybek Ashirov, Farkhod Eshboev, Khayotjon Dolimov, Saodat Gaynazarova, Tulkin Sadullaev, Oygul Yarilkaganova, Khusan Nasriddinov, Asadali Baymirzaev, Artyom Makhnyov, Shakhnoz Azimova   +12 more
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