Results 31 to 40 of about 12,753 (213)

Targeting purine metabolism in ovarian cancer

Journal of Ovarian Research, 2022
Purine, an abundant substrate in organisms, is a critical raw material for cell proliferation and an important factor for immune regulation. The purine de novo pathway and salvage pathway are tightly regulated by multiple enzymes, and dysfunction in ...
Jingchun Liu, Shasha Hong, Jiang Yang, Xiaoyi Zhang, Ying Wang, Haoyu Wang, Jiaxin Peng, Li Hong   +7 more
doaj   +1 more source

Trypanosoma brucei methylthioadenosine phosphorylase protects the parasite from the antitrypanosomal effect of deoxyadenosine [PDF]

, 2016
Trypanosoma brucei causes African sleeping sickness for which no vaccine exists and available treatments are of limited use due to their high toxicity or lack of efficacy. T.
de Koning, Harry P., Hofer, Anders, Pavlova, Anna, Ranjbarian, Farahnaz, Vodnala, Munender   +4 more
core   +1 more source

Purine Nucleoside Phosphorylase Deficiency [PDF]

Arthritis & Rheumatism, 1979
AbstractThe biochemical features of two families with purine nucleoside phosphorylase deficiency are compared. Laboratory studies and an evaluation of kinetic and physical properties of erythrocyte purine nucleoside phosphorylase give evidence that a) the degree of abnormality in uric acid and nucleoside concentrations in plasma and urine reflect the ...
Robert L. Wortmann, Catherine Andres, Janice Kaminska, Edwin Mejias, Erwin Gelfand, William Arnold, Kenneth Rich, Irving H. Fox   +7 more
openaire   +1 more source

Ischemic nucleotide breakdown increases during cardiac development due to drop in adenosine anabolism/catabolism ratio [PDF]

, 1990
Our earlier work on reperfusion showed that adult rat hearts released almost twice as much purine nucleosides and oxypurines as newborn hearts did [Am J Physiol 254 (1988) H1091].
Huizer, T. (Tom), Jong, J.W. (Jan Willem) de, Keijzer, E. (Elisabeth), Schoutsen, B.   +3 more
core   +2 more sources

Pyrimidine biosynthesis is not an essential function for trypanosoma brucei bloodstream forms [PDF]

, 2013
<p>Background: African trypanosomes are capable of both pyrimidine biosynthesis and salvage of preformed pyrimidines from the host, but it is unknown whether either process is essential to the parasite.</p> <p>Methodology/Principal ...
A Hofer, Anne Donachie, B Aronow, B Rodenko, BA Fox, Ben L. Kelly, CC Wang, D Bi, Daniel N. A. Tagoe, DB Longley, DJ Hammond, ET Larson, G Gao, G Priotto, H Hirumi, Harry P. de Koning, HF Hassan, HMS Ibrahim, HP De Koning, HP De Koning, HP De Koning, HP De Koning, HP De Koning, HP De Koning, IG Papageorgiou, JA Ali, Jane C. Munday, JB French, Juma A. M. Ali, K Van Dyke, KL Martin, Liam J. Morrison, LJ Wallace, M Balasegaram, M Berg, M Berg, MD Scahill, MI Al-Salabi, MJ Natto, MK Gould, N Sienkiewicz, N Sternberg, PI Fields, R Brun, R Brun, S Gudin, S Lillico, SM Landfear, TL Arakaki, V Bellofatto, VM Castillo-Acosta, ZN Wilson   +51 more
core   +4 more sources

Pyrazolo[4,3-e][1,2,4]triazines: Purine Analogues with Electronic Absorption in the Visible Region

Molecules, 2005
Synthesis of several pryrazolo[4,3-e][1,2,4]-triazines is described. Theabsorption spectrum of some 5-substituted derivatives was found to extend to the visibleregion.
Jacek Wierzchowski, Andrzej Rykowski, Mariusz Mojzych   +2 more
doaj   +1 more source

Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy [PDF]

, 2017
Leishmania pyrimidine salvage is replete with opportunities for therapeutic intervention with enzyme inhibitors or antimetabolites. Their uptake into cells depends upon specific transporters; therefore it is essential to establish whether various ...
Ali, Juma A.M., Alzahrani, Khalid J.H., Barrett, Michael P., Creek, Darren J., De Koning, Harry P., Eze, Anthonius A., Looi, Wan Limm, Tagoe, Daniel N.A.   +7 more
core   +2 more sources

Characterization of an engineered human purine nucleoside phosphorylase fused to an anti-her2/neu single chain Fv for use in ADEPT [PDF]

, 2009
Background Antibody Directed Enzyme Prodrug Therapy (ADEPT) can be used to generate cytotoxic agents at the tumor site. To date non-human enzymes have mainly been utilized in ADEPT.
Sepideh Afshar, Tove Olafsen, Anna M Wu, Sherie L Morrison, KD Bagshawe, KD Bagshawe, G Xu, CJ Springer, S Afshar, JD Stoeckler, R Schier, JS Dela Cruz, RJ Pietras, S Marqusee, R Arai, F Canduri, S Afshar, SE Ealick, A Berezov, P Wang, A Bzowska, GP Adams, G Adams, JS Hong, BW Hughes, WB Parker, RJ Francis, S Carmicle, SJ Landry   +28 more
core   +1 more source

Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model. [PDF]

PLoS ONE, 2011
Plasmodium falciparum causes most of the one million annual deaths from malaria. Drug resistance is widespread and novel agents against new targets are needed to support combination-therapy approaches promoted by the World Health Organization. Plasmodium
María B Cassera, Keith Z Hazleton, Emilio F Merino, Nicanor Obaldia, Meng-Chiao Ho, Andrew S Murkin, Richard DePinto, Jemy A Gutierrez, Steven C Almo, Gary B Evans, Yarlagadda S Babu, Vern L Schramm   +11 more
doaj   +1 more source

Ethenoguanines undergo glycosylation by nucleoside 2'-deoxyribosyltransferases at non-natural sites. [PDF]

PLoS ONE, 2014
Deoxyribosyl transferases and functionally related purine nucleoside phosphorylases are used extensively for synthesis of non-natural deoxynucleosides as pharmaceuticals or standards for characterizing and quantitating DNA adducts.
Wenjie Ye, Debamita Paul, Lina Gao, Jolita Seckute, Ramiah Sangaiah, Karupiah Jayaraj, Zhenfa Zhang, P Alexandre Kaminski, Steven E Ealick, Avram Gold, Louise M Ball   +10 more
doaj   +1 more source