Results 41 to 50 of about 6,269 (167)

Control Strategies in Guanine Biocrystallization

Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.
Biological guanine crystals produce spectacular photonic phenomena in animals and hold great promise as new, sustainable optical materials. We review how organisms precisely control the structure, morphologies, and resulting optical properties of these crystals using a set of ingenious ‘design’ strategies, including control of pH, template‐directed ...
Shashanka S. Indri, Avital Wagner, Benjamin A. Palmer   +2 more
wiley   +2 more sources

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, Volume 13, Issue 35, 24 June 2026.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Insights into phosphate cooperativity and influence of substrate modifications on binding and catalysis of hexameric purine nucleoside phosphorylases. [PDF]

PLoS ONE, 2012
The hexameric purine nucleoside phosphorylase from Bacillus subtilis (BsPNP233) displays great potential to produce nucleoside analogues in industry and can be exploited in the development of new anti-tumor gene therapies.
Priscila O de Giuseppe, Nadia H Martins, Andreia N Meza, Camila R dos Santos, Humberto D'Muniz Pereira, Mario T Murakami   +5 more
doaj   +1 more source

Boron‐10 carriers and their applications in boron neutron capture therapy

Precision Radiation Oncology, Volume 10, Issue 2, Page 205-241, June 2026.
Summary of different types of boron drugs. Abstract Boron neutron capture therapy (BNCT) has emerged as a promising therapeutic modality in cancer treatment, demonstrating the ability to selectively eliminate cancer cells through the 10B(n,α)7Li nuclear reaction with minimal side effects on normal tissues.
Dachao Tang, Mengqi Shi, Zhichen Mao, Weiya Chen, Xiaoling Li, Xiao Yan Zhao, Zhigang Liu, Xiao Xu   +7 more
wiley   +1 more source

Structural insights into urocanate reductase using room‐temperature X‐ray crystallography

Acta Crystallographica Section D, Volume 82, Issue 6, Page 603-614, June 2026.
The active‐site dynamics of the microbial enzyme urocanate reductase were revealed by room‐temperature X‐ray crystallography.Urocanate reductase (UrdA) is a bacterial enzyme that converts urocanic acid to imidazole propionate. Its catalytic residue Arg411 undergoes a large conformational change in the substrate‐bound versus product‐bound states.
Swati Aggarwal, Nitisha Gurav, Esko Oksanen, Karin Lindkvist-Petersson, Raminta Venskutonytė   +4 more
wiley   +1 more source

Metabolic Strategies Under Heat Stress in Non‐Adapted and High‐Temperature‐Adapted Lines of a Marine Diatom

Environmental Microbiology, Volume 28, Issue 6, June 2026.
Proteomics reveal Chaetoceros simplex‐evolved populations adopt a conservative, resource‐recycling strategy when exposed to above‐optimal temperatures. This involves downregulating biosynthesis, which helps the organism withstand heat stress. However, this strategy may limit their ability to adapt to high temperatures in environments with low nitrate ...
María Aranguren‐Gassis, Angel P. Diz, Suzana G. Leles, María Huete‐Ortega, Andrew Allen, Naomi M. Levine, Elena Litchman   +6 more
wiley   +1 more source

Gene Expression and Structural Differences Underpinning Black and White Colouration in Spiders

Molecular Ecology, Volume 35, Issue 12, June 2026.
ABSTRACT The presence of multiple color variants within a single population, known as color polymorphism, is a striking example of intraspecific phenotypic variation and a model for studying evolutionary processes. These processes depend on the underlying mechanisms such as the genes and pigments involved; but we currently lack such information for non‐
Fabian C. Salgado‐Roa, Devi Stuart‐Fox, Laura Ospina‐Rozo, Iliana Medina   +3 more
wiley   +1 more source

Tri-Cyclic Nucleobase Analogs and Their Ribosides as Substrates of Purine-Nucleoside Phosphorylases. II Guanine and Isoguanine Derivatives

Molecules, 2019
Etheno-derivatives of guanine, O6-methylguanine, and isoguanine were prepared and purified using standard methods. The title compounds were examined as potential substrates of purine-nucleoside phosphorylases from various sources in the reverse ...
Alicja Stachelska-Wierzchowska, Jacek Wierzchowski, Michał Górka, Agnieszka Bzowska, Beata Wielgus-Kutrowska   +4 more
doaj   +1 more source

Luminescence of N2,3‐etheno‐2‐aminopurine Embedded in Polyvinyl Alcohol Films at Room Temperature

Luminescence, Volume 41, Issue 5, May 2026.
The spectral characteristics of N2,3‐etheno‐2‐aminopurine immobilized in poly(vinyl alcohol) films are presented. Direct excitation to the triplet state and the occurrence of room‐temperature phosphorescence were observed. These findings could be useful for developing tools to study biomolecules that are unstable under high‐energy excitation.
Beata Wielgus‐Kutrowska, Jacek Wierzchowski, Alicja Stachelska‐Wierzchowska, Joanna Krasowska, Bong Lee, Agnieszka Jablonska, Magdalena W. Duszka, Michał F. Rode, Rajveer Sagoo, Danh Pham, Trang Thien Pham, Zygmunt Gryczynski, Ignacy Gryczynski   +12 more
wiley   +1 more source

A β-Fluoroamine Inhibitor of Purine Nucleoside Phosphorylase [PDF]

Journal of Medicinal Chemistry, 2008
The potent immucillin purine nucleoside phosphorylase (PNP ) inhibitors F-DADMe-ImmH [(3S,4S)-3], and [(3R,4R)-3] are synthesized in seven steps. Cycloaddition to a fluoroalkene and an enzymic resolution are the key features of the construction of the fluoropyrrolidines 11, from which the immucillins are assembled by use of a three-component Mannich ...
Jennifer M, Mason, Andrew S, Murkin, Lei, Li, Vern L, Schramm, Graeme J, Gainsford, Brian W, Skelton   +5 more
openaire   +2 more sources