Results 61 to 70 of about 12,753 (213)
Pharmacoepidemiology and Drug Safety, Volume 35, Issue 4, April 2026.ABSTRACT Immunocompromised individuals experience an impaired immune function due to conditions that might be either congenital or acquired over the course of their lives. Epidemiological studies often rely on clinical definitions which, in some cases, benefit from being translated into machine‐readable algorithms for application to electronic health ...
Judit Riera‐Arnau +62 more
wiley +1 more source
, 2014 The standard of care for patients suffering cancer often includes treatment with nucleoside analogues (NAs). NAs are internalized by cell-specific nucleobase/nucleoside transporters and, after enzymatic activation (often one or more phosphorylation steps)
Balzarini, Jan +2 more
core
Pinpointing dynamic coupling in enzymes for efficient drug design [PDF]
, 2016 Enzymes are proteins that catalyze almost every chemical reaction in living systems, achieving rate enhancements of up to 21 orders of magnitude relative to the uncatalyzed reactions.
Glasstone S, Haldane JBS, Polanyi M
core +1 more source
A Simple Method for RNA‐Seq of Manually Isolated Chromatophores in Oryzias Fishes
Development, Growth &Differentiation, Volume 68, Issue 3, April 2026.ABSTRACT RNA sequencing (RNA‐seq) has become an essential tool for analyzing gene expression and exploring cell type–specific transcriptomes. However, sample preparation and quality control remain challenging, as current approaches typically rely on dissecting tissues containing mixed cell populations or using flow cytometry to isolate fluorescently ...
Makoto Goda +11 more
wiley +1 more source
Global transcriptome response in during growth on ribose [PDF]
, 2011 Background Lactobacillus sakei is valuable in the fermentation of meat products and exhibits properties that allow for better preservation of meat and fish. On these substrates, glucose and ribose are the main carbon sources available for growth. We used
Naterstad Kristine +3 more
core +2 more sources
The cytokinesis regulator RacGAP1 is a Rac1‐specific GAP on membranes
Protein Science, Volume 35, Issue 3, March 2026.Abstract Rho family small GTPases are essential for cytokinesis completion. RacGAP1, a dimeric multidomain protein with a lipid‐binding C1 domain and a GTPase‐activating protein (GAP) domain, is a major regulator in this process. However, despite many cellular and biochemical studies, whether RhoA or Rac1 is the actual substrate inactivated by RacGAP1 ...
Pavlina Dubois +5 more
wiley +1 more source
Advanced Synthesis &Catalysis, Volume 368, Issue 1, January 2026.Al‐Hilfi et al. present a biocatalytic strategy for synthesizing 5‐methyl‐5,6‐dihydrothymidine (5‐MDHT), a sensitive MRI contrast agent. The study demonstrates that recombinant enzyme catalysis offers an efficient, sustainable, and eco‐friendly alternative to traditional chemical synthesis for producing clinically relevant imaging probes.
Aimen Al‐Hilfi +8 more
wiley +1 more source
Molecules, 2019 Etheno-derivatives of guanine, O6-methylguanine, and isoguanine were prepared and purified using standard methods. The title compounds were examined as potential substrates of purine-nucleoside phosphorylases from various sources in the reverse ...
Alicja Stachelska-Wierzchowska +4 more
doaj +1 more source
Proteomic alterations of Escherichia coli by paraquat [PDF]
, 2010 Paraquat (PQ; a widely used herbicide) exerts its harmful effect to human, mammals and microorganisms upon intracellular conversion to superoxide radical.
Isarankura-Na-Ayudhya, Chartchalerm +7 more
core
Journal of Clinical Laboratory Analysis, Volume 40, Issue 2, January 2026.We evaluated a colorimetric assay using clinical reagents for determining Ca, IP, and Zn in human milk. Significant correlations were observed between Ca, IP, and Zn levels determined by colorimetric assay and Ca, total P, and Zn levels determined by ICP‐AES.
Miori Tanaka +3 more
wiley +1 more source