Results 71 to 80 of about 12,753 (213)

Characterization and Antibody Preparation of the Gene Products of Grouper Iridovirus ORF5L

Aquaculture, Fish and Fisheries, Volume 5, Issue 6, December 2025.
ABSTRACT Grouper iridovirus (GIV) is a large DNA virus belonging to the family Iridoviridae and genus Ranavirus. It consists of 139,793 base pairs (bp) and 120 open reading frames (ORFs). GIV is a key pathogen of farmed fish worldwide. The functional roles of viral genes must be determined for the early diagnosis, treatment and prevention of viral ...
Chu‐Fan Cheng, Hsiang‐Chieh Chuang, Yu‐Shen Lai   +2 more
wiley   +1 more source

Distributed Kernel K-Means for Large Scale Clustering

, 2017
Clustering samples according to an effective metric and/or vector space representation is a challenging unsupervised learning task with a wide spectrum of applications.
Decherchi, Sergio, Ferrarotti, Marco Jacopo, Rocchia, Walter   +2 more
core   +1 more source

Nucleoside-dependent synthesis of organic phosphorus compounds by rat liver nuclei [PDF]

, 1967
a) A modified procedure of the WIDNELL and TATA8 method yields rat liver nuclei manifesting a high degree of purity and activity. b) These nuclei contain a nucleoside-dependent phosphorylating activity that is readily released and apparently unrelated to
Utsumi, Kozo
core   +1 more source

Identification of Candidate Blood Biomarkers of Recombinant Human Erythropoietin Administration Using Targeted Polar Metabolomics by HILIC‐MS/MS

Drug Testing and Analysis, Volume 17, Issue 12, Page 2323-2332, December 2025.
Using targeted HILIC‐MS/MS metabolomics, inosine and hypoxanthine were identified as potential biomarkers of EPO administration. Their consistent and sensitive plasma responses highlight their promise for inclusion in the Athlete Biological Passport (ABP), warranting further investigation to enhance anti‐doping detection strategies. ABSTRACT Increasing
Olivier Salamin, Lejla Ramic, Raul Nicoli, Serge Rudaz, Davy Guillarme, Tiia Kuuranne   +5 more
wiley   +1 more source

A Comprehensive Review of Probiotics in Alleviating Hyperuricemia: Mechanisms, Strain Engineering, and Food Applications

Food Bioengineering, Volume 4, Issue 4, Page 546-563, December 2025.
Screening and modification of probiotics that can efficiently reduce uric acid provide a new strategy for food‐grade hyperuricemia intervention. ABSTRACT Hyperuricemia has become one of the most prevalent global epidemics, significantly impacting both the economy and the health of individuals.
Le Wang, Qi Wu, Mengjia Zhang, Zifu Ni, Pengshuai Zhang, Siyuan Bai, Yibin Wang, Zhongke Sun   +7 more
wiley   +1 more source

Mycoplasma hyorhinis‐encoded cytidine deaminase efficiently inactivates cytosine‐based anticancer drugs

FEBS Open Bio, 2015
Mycoplasmas may colonize tumor tissue in patients. The cytostatic activity of gemcitabine was dramatically decreased inMycoplasma hyorhinis‐infected tumor cell cultures compared with non‐infected tumor cell cultures.
Johan Vande Voorde, Peter Vervaeke, Sandra Liekens, Jan Balzarini   +3 more
doaj   +1 more source

The Influence of Schwann Cell Metabolism and Dysfunction on Axon Maintenance

Glia, Volume 73, Issue 12, Page 2338-2352, December 2025.
Main Points Sensory neurons depend on Schwann cells for survival. Schwann cells provide energy for axons dunng rapid firing or after injury. Dysregulated metabolism in Schwann cells can lead to the production of neurotoxic and axon degeneration. ABSTRACT Schwann cells are the glial cells in the peripheral nervous system responsible for the production ...
Rose Follis, Vishwanath V. Prabhu, Bruce D. Carter   +2 more
wiley   +1 more source

A specific adenosine phosphorylase, distinct from purine nucleoside phosphorylase

FEBS Letters, 1976
Several enzymes, catalyzing the reversible phosphorolysis of purine nucleosides have been described in eucaryotic cells and in micro-organisms [l-6] . The best known is the ‘purine nucleoside phosphorylase’ (EC 2.4.2.1) acting on the nucleosides of hypoxanthine and guanine. Adenosine is not used as substrate by this enzyme [6-81.
SENESI, SONIA, FALCONE, GIUSEPPE, MURA, UMBERTO, SGARRELLA F, IPATA, PIERO LUIGI   +4 more
openaire   +5 more sources

Cordyceps sinensis (CS) Alleviates Chronic Obstructive Pulmonary Disease Symptoms (COPD) by Targeting Inflammation, Apoptosis, and Oxidative Stress Through Ingredient–Gene–Disease Interaction

Immunity, Inflammation and Disease, Volume 13, Issue 12, December 2025.
Our findings indicate that Cordyceps Sinensis (CS) alleviates COPD symptoms by inhibiting inflammation and oxidative stress, with key biomarkers such as interleukins (ILs), tumor necrosis factor (TNF), and reactive oxygen species (ROS) identified. Activating autophagy serves as a protective mechanism against COPD development induced by oxidative stress.
Zirui Zang, Yuhan Kong, Qi Kong
wiley   +1 more source

Purine nucleoside phosphorylase (PNP) deficiency: across-the-board severe combined immunodeficiency

Egyptian Journal of Medical Human Genetics
Background Purine nucleoside phosphorylase (PNP) deficiency is a rare, autosomal recessive, inborn error of immunity. It is characterized by progressive immune abnormalities ranging from severe combined immunodeficiency (SCID) to combined ...
Engy A. Chohayeb, Sohilla Lotfy, Rabab E. El Hawary, Safa S. Meshaal, Iman A. Mansour, Nermeen M. Galal, Aisha M. Elmarsafy   +6 more
doaj   +1 more source