Results 301 to 310 of about 311,690 (329)

A short peptide derived from late embryogenesis abundant proteins enhances acid tolerance in Escherichia coli via modulation of two‐component regulatory systems

The FEBS Journal, EarlyView.
Expression of the LEA‐K peptide in E. coli BL21 (DE3) improved bacterial viability under acidic stress (pH4), suggesting a protective function. RNA‐sequencing of LEA‐K‐expressing vs. non‐expressing cells revealed 283 differentially expressed genes (DEGs). In silico docking linked LEA‐K to two‐component systems (TCS) proteins (Rcs, BtsS/R, and EnvZ/OmpR)
Khaled Metwally, Shinya Ikeno
wiley   +1 more source

DNA adenine methylation influences gene expression and biofilm formation in <i>Streptococcus mutans</i>. [PDF]

Appl Environ Microbiol
Zhao H, Dufour D, Ghobaei N, Bozec L, Lévesque CM.   +4 more
europepmc   +1 more source

Zebrafish as a model for Catel–Manzke syndrome—identification and characterization of the zebrafish TGDS ortholog

The FEBS Journal, EarlyView.
Zebrafish Tgds, when expressed as a recombinant protein, catalyzes the dehydration of UDP‐D‐glucose, the initial step in the formation of 6‐deoxyhexoses. Corresponding Tgds mutations found in Catel–Manzke syndrome patients lead to reduced enzymatic activity and stability.
Maria Rosaria Coppola, Deianira Bellitto, Erfan Asgari, Virginia Bazzurro, Giorgia Casucci, Francesco Piacente, Matteo Bozzo, Davide Ceresa, Costantino Parisi, Cecilia Winata, Simona Candiani, Michela Tonetti   +11 more
wiley   +1 more source

DNA base pairs: the effect of the aromatic ring on the strength of the Watson-Crick hydrogen bonding.

Org Biomol Chem
Nieuwland C, van Well MJ, Guillaumes L, de Vey Mestdagh A, Dekker L, Nieuweboer C, Simon S, Fonseca Guerra C.   +7 more
europepmc   +1 more source

CRISPR/Cas9 mediated ENT2 gene knockout altered purine catabolic pathway and induced apoptosis in colorectal cell lines. [PDF]

PLoS One
Naes SM, Ab-Rahim S, Mazlan M, Syafruddin SE, Mohtar MA, Abuhamad AY, Abdul Rahman A.   +6 more
europepmc   +1 more source

Multi‐pathway‐driven hepatic protection: Semaglutide combined with HIIT counteracts diabetic liver injury in db/db mice

Journal of Diabetes Investigation, EarlyView.
This study reveals that the new drug semaglutide combined with high‐intensity interval training is significantly better than a single drug in improving liver metabolic abnormalities in type 2 diabetes. Untargeted metabolomics studies showed that the synergistic effect was mainly achieved by regulating key pathways such as the TCA cycle, amino acid ...
Wenjun Yu, Yongfu Liu, Shenglong Le, Yuxin Xiao, Xiaoyan Chen, Junhua Wang, Feng Gao   +6 more
wiley   +1 more source

The NUDIX hydrolase NUDT5 regulates thiopurine metabolism and cytotoxicity. [PDF]

J Clin Invest
Maillard M, Nishii R, Vu HS, Bhattarai KR, Yang W, Li J, Hofmann U, Savic D, Bhatia S, Schwab M, Ni M, Yang JJ.   +11 more
europepmc   +1 more source

Retinopathy-associated inosine monophosphate dehydrogenase 1 mutations cause metabolic and filament defects in cones.

Dis Model Mech
Rutter KM, Giarmarco MM, Truong V, Wang Y, Eminhizer M, Xiang Y, Cleghorn WM, Sanchez G, Burrell AL, Kollman JM, Du J, Brockerhoff SE.   +11 more
europepmc   +1 more source

Conserved interfaces mediate multiple protein-protein interactions in a prokaryotic metabolon. [PDF]

Mol Syst Biol
Bhattacharyya S, Ranganathan S, Chowdhury S, Adkar BV, Khrapko M, Shakhnovich EI.   +5 more
europepmc   +1 more source