Results 111 to 120 of about 677,954 (299)

Beta-hydroxyphosphonate ribonucleoside analogues derived from 4-substituted-1,2,3-triazoles as IMP/GMP mimics: synthesis and biological evaluation

Beilstein Journal of Organic Chemistry, 2016
A series of seventeen β-hydroxyphosphonate ribonucleoside analogues containing 4-substituted-1,2,3-triazoles was synthesized and fully characterized. Such compounds were designed as potential inhibitors of the cytosolic 5’-nucleotidase II (cN-II), an ...
Tai Nguyen Van, Audrey Hospital, Corinne Lionne, Lars P. Jordheim, Charles Dumontet, Christian Périgaud, Laurent Chaloin, Suzanne Peyrottes   +7 more
doaj   +1 more source

1,2,3-Triazoles as leaving groups in S_NAr-Arbuzov reactions: synthesis of C6-phosphonated purine derivatives. [PDF]

Beilstein J Org Chem, 2021
Kriķis KĒ, Novosjolova I, Mishnev A, Turks M.   +3 more
europepmc   +1 more source

Regioselective Nucleophilic Aromatic Substitution of 2,6-Bis-(1,2,3-Triazolyl)-Purine Derivatives with Various Nucleophiles

A novel class of bis-triazolyl purine nucleosides were obtained from 2,6-diazido precursors via copper (I) catalyzed azide-alkyne cycloaddition. These intermediates appeared to be very reactive towards N- and S-nucleophiles and thus selectively gave C(6)-
Bizdēna, Ērika, Novosjolova, Irina, Turks, Māris   +2 more
core  

Host‐Specific Interactions Between Staphylococcus aureus and Pseudomonas aeruginosa Impair Epithelial Repair in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) is frequently associated with polymicrobial biofilms involving Staphylococcus aureus and Pseudomonas aeruginosa. Interactions between these organisms are thought to influence disease severity, but the epithelial effects of exoproteins derived from patient‐matched cocultures remain poorly defined ...
Xiaohan Sun, Mahnaz Ramezanpour, George Bouras, Emma Barry, Alkis J. Psaltis, Peter‐John Wormald, Sarah Vreugde   +6 more
wiley   +1 more source

Purine and its derivatives

, 2019
Purini i njegovi derivati su heterociklički aromatski spojevi sastavljeni od pirimidinskog prstena spojenog na imidazolni prsten, te predstavljaju najznačajniju skupinu spojeva s dva kondenzirana heterociklička prstena.
Peranović, Katarina
core   +1 more source

Novel Bis- and Mono-Pyrrolo[2,3-d]pyrimidine and Purine Derivatives: Synthesis, Computational Analysis and Antiproliferative Evaluation. [PDF]

Molecules, 2021
Bistrović Popov A, Vianelo R, Grbčić P, Sedić M, Pavelić SK, Pavelić K, Raić-Malić S.   +6 more
europepmc   +1 more source

Derivatives of 2,6-Diazidopurine and 2,6-Bis-(1,2,3-Triazol-1-yl) Purine as Useful Intermediates in the Synthesis of Modified Purine Nucleosides

Novel 2,6-bis-(1,2,3-triazol-1-yl)purine, N6-substituted-2-(1,2,3-triazol-1-yl)adenine and 6-alkyl/arylthio-2-(1,2,3-triazol-1-yl)purine and 2-alkylthio-6-(1,2,3-triazol-1-yl)purine nucleosides were synthesized.
Bizdēna, Ērika, Novosjolova, Irina, Turks, Māris   +2 more
core  

Systematic pathway‐level analysis defines conserved transcriptional divergence between primary lung tumors and cell line models

Animal Models and Experimental Medicine, EarlyView.
Lung cancer cell lines diverge substantially from primary tumors at the transcriptional level. Using single‐sample gene set enrichment analysis and L1‐penalized feature selection across TCGA‐LUAD and CCLE‐LUAD, we identified five Hallmark pathways (E2F targets, G2M checkpoint, IFNγ response, coagulation, and EMT) that discriminated primary tumors from ...
Pritam Bera, Rajesh Raju, Debodipta Das
wiley   +1 more source

2,6-Bis-Triazolyl Purine Deoxyribo-Nucleosides and Their Reactions with N-Nucleophiles

New 2,6-bis-triazolyl derivatives of purine deoxyribo-nucleosides have been synthesized and their reactions with piperidine and pyrrolidine have been ...
Cīrule, Dace, Bizdēna, Ērika, Novosjolova, Irina, Ozols, Kristers   +3 more
core  

Aminomalononitrile inspired prebiotic chemistry as a novel multicomponent tool for the synthesis of imidazole and purine derivatives with anti-influenza A virus activity. [PDF]

RSC Adv, 2021
Bizzarri BM, Fanelli A, Botta L, De Angelis M, Palamara AT, Nencioni L, Saladino R.   +6 more
europepmc   +1 more source