Results 131 to 140 of about 677,954 (299)

Estudos de relações preditivas entre a estrutura e a atividade para inibição enzimática e analgesia / [PDF]

, 1999
Tese (Doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e ...
Andricopulo, Adriano Defini
core  

Treatment‐driven peripheral blood transcriptomic remodelling and baseline predictors of ESSDAI and STAR response to B‐cell therapy in Sjögren's disease

Arthritis &Rheumatology, Accepted Article.
Objective To characterise whole‐blood transcriptomic profiles in adults with active Sjögren's disease (SjD) treated with anti‐CD20 or BlyS/BAFF inhibition, identify markers of clinical response, and define inflammatory pathways linked to non‐response. Methods Whole‐blood RNA sequencing was performed at baseline and week‐24 in participants (n=43) from a
Aimen Ibrahim, Junjie Peng, Eileen Tian, Lucia Martin‐Gutierrez, John Casement, Kyle Thompson, Wan‐Fai Ng, André van Maurik, Elizabeth C Jury, Coziana Ciurtin   +9 more
wiley   +1 more source

New Achievements in the Chemistry of Triazolyl Purine Nucleosides

Synthesis of novel 2- and 6-alkyl/arylthiopurine derivatives was developed. Reactions were carried out between 2,6-diazidopurine, 2,6-dichloropurine and 2,6-bis-triazolylpurine derivatives and different S-nucleophiles.
Bizdēna, Ērika, Novosjolova, Irina, Turks, Māris   +2 more
core  

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Purine-based chemical probe with HOMO switching for intracellular detection of mercury ions

Scientific Reports
The detailed photophysical characterization of 2-piperidinyl-6-triazolylpurine derivatives and their complexes with metal ions is presented. The studied compounds contain two electron donating units – piperidine and methoxyphenyl, while triazolyl-purine ...
Kamilė Boguševičienė, Justina Jovaišaitė, Gediminas Jonusauskas, Gediminas Kreiza, Aleksejs Burcevs, Zigfrīds Kapilinskis, Irina Novosjolova, Maris Turks, Li Er Hean, Han-Wei Chu, Huang-Tsung Chang, Saulius Juršėnas   +11 more
doaj   +1 more source

Beyond antimicrobials: Ecological nano‐strategies for rebalancing dysbiotic oral microbial homeostasis

BMEMat, EarlyView.
Oral microbial homeostasis, a dynamic host‐microbe balance, is vital in infectious diseases. Conventional antibiotics often disrupt this homeostasis, spurring interest in nanomaterials for oral microbial homeostasis rebalancing. This review outlines nanomaterial strategies across three ecological levels (population/community, ecosystem, and cross ...
Chen Hu, Aohan Luan, Yujun Yang, Linlin Wang, Huilin Wang, Ning Wang, Guixin He, Yajie Yang, Rabiya Noor, Jawad Hussain, Longquan Shao   +10 more
wiley   +1 more source

RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging

Biological Reviews, EarlyView.
ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad, Suresha G. Prabhu, Lizna M. Ali, Vineeta N. Pillai, Farah Mustafa, Tahir A. Rizvi   +5 more
wiley   +1 more source

Studies of new purine derivatives with acetic acid moiety in human keratinocytes [PDF]

, 2017
Recently we described a group of purine derivatives based on theophylline structure with acetic acid moiety. Studies in a group of these compounds demonstrated their analgesic and anti-inflammatory properties.
Stalińska, Joanna, Koczurkiewicz, Paulina, Chłoń-Rzepa, Grażyna, Wójcik-Pszczoła, Katarzyna, Wyszkowska-Kolatko, Magdalena, Pękala, Elżbieta, Drukała, Justyna   +6 more
core  

Control of Gemcitabine Activity With Blue and Red Light

Chemistry – A European Journal, EarlyView.
Treating cancer with chemotherapy is generally associated with many side effects, which can be addressed by selectively releasing the desired drugs with visible light. Sixteen new blue light‐activatable cytostatics were introduced, with the gemcitabine derivative exhibiting ideal properties.
Nils F. Kersten, Konstantin L. Stock, Marius Hyprath, Hannah Weisser, Timo Weinrich, Dieter Steinhilber, Alexander Heckel   +6 more
wiley   +1 more source