Results 151 to 160 of about 1,617,490 (298)

Farnesoid X receptor prevents hyperuricemia via activating ATP‐binding cassette subfamily G member 2

Rheumatology &Autoimmunity, EarlyView.
Farnesoid X receptor (FXR) activation reduces serum uric acid levels by upregulating the intestinal urate transporter ATP‐binding cassette subfamily G member 2 (ABCG2). These findings uncover a novel metabolic pathway for urate excretion and suggest that FXR agonists (e.g., obeticholic acid), represent a promising therapeutic strategy for the treatment
Rui Li, Guo Tang, Ye Yu, Guang‐Liang Chen, Liangjing Lu, Juan Wang   +5 more
wiley   +1 more source

Approaching Gold‐Standard Sensitivity in a Portable and Versatile Gold Nanoprisms Thermoplasmonic Platform for Lateral Flow Detection of Biomolecules

Small, EarlyView.
This study presents a plasmonic thermal lateral flow (ThermoLFA) biosensor for ultrasensitive, early detection of biomolecules. By combining plasmonic gold nanoprisms (AuNPrs) and near‐infrared (NIR) laser activation, it enhances signal output beyond conventional LFAs.
Carlos Cuestas Ayllón, Alba Martín Barreiro, África García Barrientos, María Moros, Valeria Grazú Bonavía, Jesús Martínez de la Fuente   +5 more
wiley   +1 more source

The utility of pyrimidine derivatives in the construction of azolo[<i>d</i>]pyrimidine: part II-multi-nitrogen azole systems with potential biological applications. [PDF]

RSC Adv
Shamroukh AH, Rashad AE.
europepmc   +1 more source

Synthesis of 2,6-Diamino-Substituted Purine Derivatives and Evaluation of Cell Cycle Arrest in Breast and Colorectal Cancer Cells. [PDF]

Molecules, 2018
Bosco B, Defant A, Messina A, Incitti T, Sighel D, Bozza A, Ciribilli Y, Inga A, Casarosa S, Mancini I.   +9 more
europepmc   +1 more source

Amyloid‐Like Protein Assembly‐Driven Functional Materials for Enabling the Sustainable Development of Light Industry

SusMat, EarlyView.
This article covers the basic theory and regulation strategies of amyloid‐like protein assembly, reviews the research progress of amyloid‐like protein assembly‐driven functional materials in light industry fields such as food, packaging, textiles, and biocatalysis, analyzes their sustainable advantages and challenges in these applications, and offers ...
Ruirui Liu, Zuying Chen, Jian Zhao, Fengjian Wang, Changli Zeng, Peng Yang   +5 more
wiley   +1 more source

Microwave assisted synthesis of coumarin-purine derivatives: An approach to in vitro anti-oxidant, DNA cleavage, crystal structure, DFT studies and Hirshfeld surface analysis. [PDF]

Heliyon, 2019
Mangasuli SN, Hosamani KM, Managutti PB.
europepmc   +1 more source

Dimethyl‐, Diethyl‐, and Propylene Carbonates: An Emerging Class of Green Solvents for Organic Synthesis

The Chemical Record, EarlyView.
This review highlights recent advances in the use of organic carbonates, dimethyl carbonate (DMC), diethyl carbonate (DEC), and propylene carbonate (PC), as solvents in organic synthesis. Based on over seventy studies from the past 6 years, it shows their application in different organic reaction types, emphasizing their role in safer and more ...
Gabriela T. Quadros, Livia C. L. Valente, Thiago Barcellos, Daniela Hartwig, Laura Abenante, Eder J. Lenardão   +5 more
wiley   +1 more source

Comparative Molecular Insights into Developmental and Behavioral Toxicity Induced by Octocrylene and Ethylhexyl Salicylate Exposure on Zebrafish

Integrative Zoology, EarlyView.
This study compared the ecological toxicity of organic ultraviolet filters, octocrylene (OC) and ethylhexyl salicylate (EHS), on zebrafish embryos and larvae. EHS exhibited higher acute toxicity, causing increased mortality, hypoactive behavior at 50 mg/L, and disruptions in lipid homeostasis, while OC primarily affected hypoxia response and ...
Xiaoyang Lu, Li Sun, Jiao Chen, Jing Wang, Miao Guan, Shixia Xu   +5 more
wiley   +1 more source

Comparison of Three Sympatric Desert Lizards: Digestive Tract Structure, Digestive Enzyme Activities, Gut Microbiota, and Metabolites

Integrative Zoology, EarlyView.
We performed 16S rDNA sequencing and metabolite profiling for three sympatric lizard species—Teratoscincus roborowskii, Phrynocephalus axillaris, and Eremias roborowskii—and compared their goblet cell and enzyme activities in the digestive tract. Our study suggests that the dietary niche may promote divergence or convergence of microbiota across host ...
Yi Yang, Ziyi Wang, Ruichen Wu
wiley   +1 more source

High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

Integrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang, Yonggang Niu, Shengkang Men, Yanghuilin Zhang, Xiaolong Tang, Kenneth B. Storey, Qiang Chen   +6 more
wiley   +1 more source