Results 151 to 160 of about 677,954 (299)

Synthesis, Characterization, and Cytotoxic Activity Properties of Some Novel Purine Derivatives. [PDF]

J Biochem Mol Toxicol
Akdoğan N, Işgüzar A, Akkoc S, Muhammed MT, Alhag SK, Al-Shuraym LA, Dişli A.   +6 more
europepmc   +1 more source

In-silico activity prediction and docking studies of some 2, 9-disubstituted 8-phenylthio/phenylsulfinyl-9h-purine derivatives as Anti-proliferative agents. [PDF]

Heliyon, 2020
Ibrahim MT, Uzairu A, Shallangwa GA, Uba S.   +3 more
europepmc   +1 more source

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Clinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung, Nicholas Ieronimakis, Bothaina Mousa, Emily D. Sheikh, Sarah E. Ligon, Joshua W. Monson, Jennifer R. Damicis, Hillary J. Kinsman, Lydia E. Bettridge, Samuel L.M. Arnold, Edward J. Kelly, Jashvant D. Unadkat, Joanne Wang   +12 more
wiley   +1 more source

Multivariate Analysis of Linear and Nonlinear Optical Properties in Purine Derivatives: A Predictive Framework from One-Photon Absorption Spectra. [PDF]

J Phys Chem A
Andrade IR, Zucolotto Cocca LH.
europepmc   +1 more source

Promising 2,6,9-Trisubstituted Purine Derivatives for Anticancer Compounds: Synthesis, 3D-QSAR, and Preliminary Biological Assays. [PDF]

Int J Mol Sci, 2019
O Salas C, Zarate AM, Kryštof V, Mella J, Faundez M, Brea J, Loza MI, Brito I, Hendrychová D, Jorda R, Cabrera AR, Tapia RA, Espinosa-Bustos C.   +12 more
europepmc   +1 more source

Proteomic profiling of Elp1‐deficient trigeminal ganglia reveals disruption of neurotrophic and metabolic pathways in a familial dysautonomia mouse model

Developmental Dynamics, EarlyView.
Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard, Lauren Clarissa Tang, Beatrix Ueberheide, Lisa A. Taneyhill   +3 more
wiley   +1 more source

Purine Derivatives in the Management of Antiresorptive Drug-Related Osteonecrosis of the Jaw. [PDF]

Curr Health Sci J
Farajollah N, Dinca OM, Bucur MB, Vladan GC, Bucur A.   +4 more
europepmc   +1 more source

MIT/TFE family transcription factors, Mitf and Tfec, redundantly promote pigment cell differentiation and retinal epithelium pigmentation in teleosts

Developmental Dynamics, EarlyView.
Abstract Background Transcription factors of the MIT/TFE family—mitfa, mitfb, and tfec—play essential roles in specifying pigment cells derived from neural crest cells in vertebrates. In teleosts, which possess multiple pigment cell types, these factors exhibit partially redundant but largely distinct functions across different pigment lineages.
James Lister, Keisuke Sugiwaka, Tetsuaki Kimura, Rieko Tanaka, Makoto Goda, Hikaru Kobayashi, Chikako Inoue, Kawilarang W. A. Masengi, Kazunori Yamahira, Kiyoshi Naruse, Satoshi Ansai, Robert N. Kelsh, Masahiko Hibi, Hisashi Hashimoto   +13 more
wiley   +1 more source

Novel purine derivatives mitigate hypoxia ischemia related brain injury through agrin, zyxin and synaptotagmin proteins. [PDF]

Neurotherapeutics
Mabondzo A, Disdier C, Bouzid A, Larbi KS, Tsintzou A, Maïza A, Kim B, Costa N, Harati R, Nguyen AL, Pruvost A, Galons H, Oumata N, Armengaud J, Knijnenburg M, Verma G, Hagberg H, Gressens P, Chen XF, Hamoudi RA, Stonestreet BS.   +20 more
europepmc   +1 more source

Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris. [PDF]

Exp Ther Med, 2019
Nicolae I, Tampa M, Ene CD, Mitran CI, Mitran MI, Sarbu MI, Matei C, Ene C, Georgescu SR.   +8 more
europepmc   +1 more source