Results 161 to 170 of about 1,617,490 (298)

PURINE AND PYRIMIDINE DERIVATIVES IN MATURE PEA SEEDS [PDF]

Biochemical Journal, 1963
openaire   +2 more sources

Gut Microbiota of Gray Snub‐Nosed Monkeys: Adaptation to Seasonal Variations Through Energy Compensation and Thermogenesis

Integrative Zoology, EarlyView.
Based on metagenome‐assembled genomes (MAGs), the gut microbiota of the gray snub‐nosed monkeys recovered 1229 non‐redundant MAGs. The gut microbiota showed an enhanced capacity to produce energy substrates with increased conversion activity of these substrates during winter.
Yue Sun, Mingyi Zhang, Xiaochen Wang, Xiaolong Huang, Yanze Yu, Huijuan Pan, Haibo Li, Lei Shi, Wei Yang, Chen Zhang, Bo Ding, Xun Liu, Jianfeng Li, Changjiang Qian, Boxing Cheng, Chao Zhang, Jingcheng Ran, Ming Li   +17 more
wiley   +1 more source

Metabolome Diversity Enhances Resistance of Intertidal Clams to Thermal Stress

Integrative Zoology, EarlyView.
Meretrix species are widely distributed intertidal bivalves in China with significant ecological and economic importance, which are sensitive to thermal stress. Our results showed that thermal environments of clam habitats shaped metabolome diversity, which can enhance the resistance of intertidal clams to thermal stress.
Zhi Hu, Xiang‐Tao Wei, Xiaonie Lin, Linxuan Ma, Tianzhe Zhang, Yunwei Dong   +5 more
wiley   +1 more source

The roles of gut microbiota and their metabolites in uric acid-related metabolic diseases: mechanisms and therapeutic targets. [PDF]

Front Microbiol
Li H, Zhou H, Li M, Wu J, Pan L.
europepmc   +1 more source

Salivary uric acid remote serial self‐testing for prediction of adverse pregnancy outcomes of uteroplacental dysfunction

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Remote, weekly self‐testing of salivary uric acid enables longitudinal monitoring throughout pregnancy. RGB‐derived measurements are combined with maternal characteristics in a model using 4 weeks of prior data. This approach provides individualized prediction of hypertensive disorders of pregnancy and fetal growth restriction within 1 week.
Basia Chmielewska, Chao Wang, Nick Macklon, Amar Bhide, Basky Thilaganathan   +4 more
wiley   +1 more source

Ferrocenoylation of Uracil Derivatives: Study of Reaction Regioselectivity and Biological Activity. [PDF]

Molecules
Lapić J, Kuzman I, Frkanec R, Frkanec L, Djaković S.   +4 more
europepmc   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Aspartate Transporter SLC1A3 Promotes Colorectal Cancer via MDM2‐p53 Pathway and M2 Macrophage Polarization

Cancer Science, EarlyView.
SLC1A3 promotes colorectal cancer progression by transporting extracellular aspartate into tumor cells, thereby activating the PKC/MDM2/p53 pathway to enhance proliferation. Reduced extracellular aspartate, combined with p53‐dependent suppression of CSF2 and IL17C, drives M2 macrophage polarization via immune modulation, macrophage recruitment, and M2 ...
Chao Deng, You Zhou, Sijie Song, Hongtao Liu, Siqi Liao, Li Zhou, Siyuan Chen, Zhihang Zhou, Song He, Bingrong Liu   +9 more
wiley   +1 more source

Pyrimidine-containing natural products: occurrences and biological activities. [PDF]

Nat Prod Bioprospect
Yao JN, Zhu Y, Chen HP, Chen Y.
europepmc   +1 more source