Results 81 to 90 of about 58,940 (303)

Inhibiting cGAS‐STING to Preserve Mitochondrial–Nuclear Communication and Stemness in Young Tendon Stem Cells: A Hydrogel Strategy against Age‐Related Tendinopathy

Advanced Science, EarlyView.
A dual‐targeting strategy to rejuvenate aged tendons. A reactive oxygen species (ROS)‐responsive hydrogel co‐delivers a selenium nanozyme (scavenges ROS) and a STING inhibitor to tendon stem cells. This combined action restores mitochondria–nucleus communication, alleviates cellular senescence, and rejuvenates tendon regeneration, offering a novel ...
Zhuo Zhang, Weiyong Song, Heng Yin, Yi Wang, Yi Zou, Yuling Li, Yue Luo, Chao Xiang, Xiaoqin Liu, Yan Xiong, Yong Wang, Ke Jiang   +11 more
wiley   +1 more source

The use of urinary purine derivatives to estimate microbial protein supply and feed intake [PDF]

Eurasian Journal of Veterinary Sciences
The urinary excretion of allantoin was first suggested as an index of rumen microbial protein yield about 30 years ago. Major progress towards establishing a method to relate purine derivatives excretion to microbial protein yield has only been made tn ...
Şule Kaya
doaj  

X-ray crystal structures show DNA stacking advantage of terminal nitrile substitution in Ru-dppz complexes [PDF]

, 2018
The new complexes [Ru(TAP)2(11-CN-dppz)]2+, [Ru(TAP)2(11-Br-dppz)]2+and [Ru(TAP)2(11,12-diCN-dppz)]2+ are reported. The addition of nitrile substituents to the dppz ligand of the DNA photooxidising complex [Ru(TAP)2(dppz)]2+ promote π-stacking ...
Adams, Bown, Boynton, Boynton, Cardin, Cloonan, Emsley, Evans, Friedman, Ghizdavu, Gill, Hall, Hall, Hall, Hall, Hall, Hall, Hall, Hall, Heinemann, Hess, Jacquet, Kabsch, Kajouj, Keane, Keane, Keane, Le Gac, Ma, Mari, Mari, McCoy, Moriarty, Murshudov, Mårtensson, Niyazi, Ortmans, Parkhurst, Pierroz, Poulsen, Poynton, Rebarz, Schneider, Sheldrick, Shi, Song, Wachter, Wachter, Winter   +48 more
core   +1 more source

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, EarlyView.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source

Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells

Advanced Science, EarlyView.
In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu, Wenhao Zhang, Yifan Zhang, Yu He, Yi Du, Yiding Zhao, Chunmeng Yao, Shengyi Sun, Xiaoyan Sheng, Qian Gao, Chao Tong, Ling Shuai   +11 more
wiley   +1 more source

Subinhibitory concentrations of trimethoprim and sulfamethoxazole prevent biofilm formation by Acinetobacter baumannii through inhibition of Csu pilus expression [PDF]

, 2017
Acinetobacter baumannii is emerging as a multidrug-resistant nosocomial pathogen of increasing threat to human health worldwide. Pili are important bacterial virulence factors, playing a role in attachment to host cells and biofilm formation.
Feldman, Mario F, Moon, Ki Hwan, Weber, Brent S   +2 more
core   +2 more sources

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

The structural basis of unique substrate recognition by Plasmodium thymidylate kinase: Molecular dynamics simulation and inhibitory studies.

PLoS ONE, 2019
Plasmodium falciparum thymidylate kinase (PfTMK) showed structural and catalytic distinctions from the host enzyme rendering it a hopeful antiprotozoal drug target.
Mahmoud Kandeel, Yukio Kitade, Abdulla Al-Taher, Mohammed Al-Nazawi   +3 more
doaj   +1 more source

The Trichinella Super‐Pangenome Reveals the Evolution of Encapsulation and Predicted Host–Parasite Protein Interactions

Advanced Science, EarlyView.
ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv, Yi Liu, Ning Xu, Xiao Zhang, Yaming Yang, Chengyao Li, Hanhai Mao, Mingyuan Liu, Xiaolei Liu   +8 more
wiley   +1 more source

Synthesis of N-7-Substituted Purines from Imidazole Precursors

Molecules, 1999
Synthesis of purines and purine mono-1-oxides from the respective 5-substituted 4-nitroimidazole derivatives is described. The commercially available 4-nitroimidazole, in a few simple steps (including Vicarious Nucleophilic Substitution of Hydrogen), was
Stanislaw Ostrowski
doaj   +1 more source