Results 61 to 70 of about 58,940 (303)

Chemo-Enzymatic Generation of Highly Fluorescent Nucleoside Analogs Using Purine-Nucleoside Phosphorylase

Biomolecules
Chemo-enzymatic syntheses of strongly fluorescent nucleoside analogs, potentially applicable in analytical biochemistry and cell biology are reviewed. The syntheses and properties of fluorescent ribofuranosides of several purine, 8-azapurine, and etheno ...
Alicja Stachelska-Wierzchowska, Jacek Wierzchowski   +1 more
doaj   +1 more source

New Purine Derivatives from the Marine Sponge

Natural Product Communications, 2008
Four new purine analogues (nigricines 1 – 4) have been isolated from the Indonesian marine sponge Petrosia nigricans. The structures were elucidated by extensive 2D-NMR spectroscopic experiments and mass spectrometry.
Mohamed Ashour, RuAngelie Edrada-Ebel, Rainer Ebel, Victor Wray, Rob.W.M. van Soest, Peter Proksch   +5 more
doaj   +1 more source

Biotransformation of halogenated 2′-deoxyribosides by immobilized lactic acid bacteria [PDF]

, 2012
An efficient and green bioprocess is herein reported to obtain halogenated nucleosides by transglycosylation using immobilized lactic acid bacteria (LAB).
Britos, Claudia Noelia, Cappa, Valeria Alejandra, Lozano, Mario Enrique, Rivero, Cintia Wanda, Sambeth, Jorge Enrique, Trelles, Jorge Abel   +5 more
core   +1 more source

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Evaluation of methodologies of urine collection to estimate microbial synthesis in bovines diets containing or not containing lipids

Bioscience Journal, 2020
This study investigated the effectiveness of the urine sample collection method in predicting the volume urinary and synthesis of microbial nitrogen. Eight fistulated steers were used with accessible rumens and kept in individual stalls.
Laila Cecília Ramos Bendia, Carlos Augusto de Alencar Fontes, Elizabeth Fonsêca Processi, Clóvis Carlos Silveira Filho, Cláudio Teixeira Lombardi, Paulo Roberto Silveira Pimentel, Ronaldo Lopes Oliveira, Leilson Rocha Bezerra, Tiago Cunha Rocha   +8 more
doaj   +3 more sources

Recovery of intravenously infused chromium EDTA and lithium sulphate in the urine of cattle and their use as markers to measure urine volume

Animal, 2009
A series of metabolism experiments investigated the recovery of continuous-, intravenously infused chromium complexed with ethylenediamine tetra-acetic acid (CrEDTA) and lithium sulphate in the urine of cattle with a view to using the markers to estimate
M.K. Bowen, D.P. Poppi, S.R. McLennan
doaj   +1 more source

Effects of theophylline on ADCY5 activation-From cellular studies to improved therapeutic options for ADCY5-related dyskinesia patients.

PLoS ONE, 2023
We show the effects of the three purine derivatives, caffeine, theophylline, and istradefylline, on cAMP production by adenylyl cyclase 5 (ADCY5)-overexpressing cell lines.
Dirk Tänzler, Marc Kipping, Marcell Lederer, Wiebke F Günther, Christian Arlt, Stefan Hüttelmaier, Andreas Merkenschlager, Andrea Sinz   +7 more
doaj   +1 more source

Identifcation of small molecule enzyme inhibitors as broad-spectrum anthelmintics [PDF]

, 2019
Targeting chokepoint enzymes in metabolic pathways has led to new drugs for cancers, autoimmune disorders and infectious diseases. This is also a cornerstone approach for discovery and development of anthelmintics against nematode and flatworm parasites.
Aroian, Raffi V., Brindley, Paul J., Bulman, Christina A., Elfawal, Mostafa A., Helander, Jon, Janetka, James W., Mitreva, Makedonka, Rosa, Bruce A., Sakanari, Judy, Tyagi, Rahul, Wildman, Scott A.   +10 more
core   +3 more sources

Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila

Advanced Science, EarlyView.
Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu, Xuedi Zhang, Ying Zhou, Jie Zheng, Angyang Sun, Kailong Zhuang, Weiwei Bao, Guanjun Gao   +7 more
wiley   +1 more source

Forage cactus associated with different fiber sources for lactating Sindhi cows: intake, digestibility and microbial protein production

Revista Brasileira de Zootecnia, 2014
This experiment was carried to evaluate the effect of forage cactus with different fiber sources (elephant grass hay [EGH], corn straw [CS], hay of cassava shoots [HCS], fresh sugarcane bagasse [FSB], and hydrolyzed sugarcane bagasse [HSB]) on intake ...
Carla Aparecida Soares Saraiva, Severino Gonzaga Neto, Maria Fernanda Soares Queiroz, Lara Toledo Henriques, Edilson Paes Saraiva, Rômulo Pontes de Freitas Albuquerque, Vinicius de França Carvalho Fonseca, George Vieira do Nascimento   +7 more
doaj   +1 more source