Results 51 to 60 of about 58,940 (303)

Electrochemical Determination of Benzene Substituted Derivatives using Carbon Based Purine Electrodes through Electrochemical Impedance Spectroscopy

International Journal of Electrochemical Science, 2014
Purine nucleobases, guanine and adenine, are known electroactive compounds which get oxidized over the carbon electrodes. These compounds are found to react with benzene derivatives forming its adducts.
S. Baby Gayathri, P. Kamaraj, M. Arthanareeswari, S. Devi Kala   +3 more
doaj   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Versatile synthesis and biological evaluation of novel 3’-fluorinated purine nucleosides

Beilstein Journal of Organic Chemistry, 2015
A unified synthetic strategy accessing novel 3'-fluorinated purine nucleoside derivatives and their biological evaluation were achieved. Novel 3’-fluorinated analogues were constructed from a common 3’-deoxy-3’-fluororibofuranose intermediate.
Hang Ren, Haoyun An, Paul J. Hatala, William C. Stevens Jr, Jingchao Tao, Baicheng He   +5 more
doaj   +1 more source

Mass Spectrometry Study of New Polyamine Derivatives of Caffeine

Acta Chimica Slovenica, 2018
The mass spectrometric fragmentations of ten new 8-alkylaminocaffeine derivatives were investigated. The fragmentation pathways of new polyamine derivatives of caffeine on the basis of low and high-resolution electron ionization (EI) mass spectra were ...
Arleta Sierakowska, Beata Jasiewicz, Tomasz Pospieszny   +2 more
doaj   +1 more source

1,2,3-Triazoles as leaving groups: SNAr reactions of 2,6-bistriazolylpurines with O- and C-nucleophiles

Beilstein Journal of Organic Chemistry, 2021
A new approach was designed for the synthesis of C6-substituted 2-triazolylpurine derivatives. A series of substituted products was obtained in SNAr reactions between 2,6-bistriazolylpurine derivatives and O- and C-nucleophiles under mild conditions. The
Dace Cīrule, Irina Novosjolova, Ērika Bizdēna, Māris Turks   +3 more
doaj   +1 more source

Purine and pyrimidine bases as growth substances for lactic acid bacteria [PDF]

, 1941
In 1936 Richardson (1) showed that uracil was essential for the anaerobic growth of Staphylococcus aureus, but not for aerobic growth of the same organism.
Mitchell, Herschel K., Snell, Esmond E.
core  

Exploration of factors driving incorporation of unnatural dNTPS into DNA by Klenow fragment (DNA polymerase I) and DNA polymerase {alpha} [PDF]

, 2006
In order to further understand how DNA polymerases discriminate against incorrect dNTPs, we synthesized two sets of dNTP analogues and tested them as substrates for DNA polymerase a (pol alpha) and Klenow fragment (exo-) of DNA polymerase I (Escherichia ...
Kincaid, Kristi, Beckman, Jeff, Zivkovic, Aleksandra, Halcomb, Randall L., Engels, Joachim W. (Prof. Dr.), Kuchta, Robert D.   +5 more
core   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Unraveling RNA contribution to the molecular origins of bacterial surface-enhanced Raman spectroscopy (SERS) signals

Scientific Reports
Surface-enhanced Raman spectroscopy (SERS) is widely utilized in bacterial analyses, with the dominant SERS peaks attributed to purine metabolites released during sample preparation.
Jun-Yi Chien, Yong-Chun Gu, Chia-Chen Chien, Chia-Ling Chang, Ho-Wen Cheng, Shirley Wen-Yu Chiu, Yeu-Jye Nee, Hsin-Mei Tsai, Fang-Yeh Chu, Hui-Fei Tang, Yuh-Lin Wang, Chi-Hung Lin   +11 more
doaj   +1 more source