Results 41 to 50 of about 1,617,490 (298)

Chemo-Enzymatic Generation of Highly Fluorescent Nucleoside Analogs Using Purine-Nucleoside Phosphorylase

Biomolecules
Chemo-enzymatic syntheses of strongly fluorescent nucleoside analogs, potentially applicable in analytical biochemistry and cell biology are reviewed. The syntheses and properties of fluorescent ribofuranosides of several purine, 8-azapurine, and etheno ...
Alicja Stachelska-Wierzchowska, Jacek Wierzchowski   +1 more
doaj   +1 more source

New Purine Derivatives from the Marine Sponge

Natural Product Communications, 2008
Four new purine analogues (nigricines 1 – 4) have been isolated from the Indonesian marine sponge Petrosia nigricans. The structures were elucidated by extensive 2D-NMR spectroscopic experiments and mass spectrometry.
Mohamed Ashour, RuAngelie Edrada-Ebel, Rainer Ebel, Victor Wray, Rob.W.M. van Soest, Peter Proksch   +5 more
doaj   +1 more source

Antimalarial activity of thiosemicarbazones and purine derived nitriles [PDF]

Bioorganic & Medicinal Chemistry Letters, 2009
Malaria is a devastating illness caused by multiple species of the Plasmodium genus. The parasite's falcipain proteases have been extensively studied as potential drug targets. Here we report the testing of two established cysteine protease inhibitor scaffolds against both chloroquine sensitive and chloroquine resistant parasites.
Jeremy P, Mallari, Wendyam A, Guiguemde, R Kiplin, Guy   +2 more
openaire   +2 more sources

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Evaluation of methodologies of urine collection to estimate microbial synthesis in bovines diets containing or not containing lipids

Bioscience Journal, 2020
This study investigated the effectiveness of the urine sample collection method in predicting the volume urinary and synthesis of microbial nitrogen. Eight fistulated steers were used with accessible rumens and kept in individual stalls.
Laila Cecília Ramos Bendia, Carlos Augusto de Alencar Fontes, Elizabeth Fonsêca Processi, Clóvis Carlos Silveira Filho, Cláudio Teixeira Lombardi, Paulo Roberto Silveira Pimentel, Ronaldo Lopes Oliveira, Leilson Rocha Bezerra, Tiago Cunha Rocha   +8 more
doaj   +3 more sources

Effects of theophylline on ADCY5 activation-From cellular studies to improved therapeutic options for ADCY5-related dyskinesia patients.

PLoS ONE, 2023
We show the effects of the three purine derivatives, caffeine, theophylline, and istradefylline, on cAMP production by adenylyl cyclase 5 (ADCY5)-overexpressing cell lines.
Dirk Tänzler, Marc Kipping, Marcell Lederer, Wiebke F Günther, Christian Arlt, Stefan Hüttelmaier, Andreas Merkenschlager, Andrea Sinz   +7 more
doaj   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

Recovery of intravenously infused chromium EDTA and lithium sulphate in the urine of cattle and their use as markers to measure urine volume

Animal, 2009
A series of metabolism experiments investigated the recovery of continuous-, intravenously infused chromium complexed with ethylenediamine tetra-acetic acid (CrEDTA) and lithium sulphate in the urine of cattle with a view to using the markers to estimate
M.K. Bowen, D.P. Poppi, S.R. McLennan
doaj   +1 more source

One-pot multi-enzymatic production of purine derivatives with application in pharmaceutical and food industry

, 2018
Biocatalysis reproduce nature’s synthetic strategies in order to synthesize different organic compounds. Natural metabolic pathways usually involve complex networks to support cellular growth and survival.
Javier Acosta, J. D. Arco, Sara Martinez-Pascual, V. J. Clemente-Suárez, J. Fernández‐Lucas   +4 more
semanticscholar   +1 more source

Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells

Advanced Science, EarlyView.
In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu, Wenhao Zhang, Yifan Zhang, Yu He, Yi Du, Yiding Zhao, Chunmeng Yao, Shengyi Sun, Xiaoyan Sheng, Qian Gao, Chao Tong, Ling Shuai   +11 more
wiley   +1 more source