Results 41 to 50 of about 58,940 (303)

Biological evaluation and molecular modelling of didanosine derivatives [PDF]

, 2014
Five carbonate derivatives of 50-O-20,30-dideoxyinosine (DDI, 1) have been synthesized by combination with aliphatic alcohols, with their in vitro anti-HIV activity and cytotoxicity being evaluated afterward in human peripheral blood mononuclear cells ...
Briñon, Margarita Cristina, de Candia, Cristian Ariel, Gualdesi, María Soledad, Pampuro, Sandra Esther, Quevedo, Mario Alfredo, Ravetti, Soledad, Turk, Gabriela Julia Ana   +6 more
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Charge Transfer-oxy Radical Mechanism for Anti-cancer Agents [PDF]

, 1986
The proposal is advanced that anti-cancer drugs generally function by charge transfer resulting in formation of toxic oxy radicals which destroy the neoplasm.
Ames, James R., Cox, O., Elo, Hannu, Kovacic, Peter, Lumme, Paavo, Ryan, Michael D.   +5 more
core   +1 more source

Anti-flavivirus activity of different tritylated pyrimidine and purine nucleoside analogues [PDF]

, 2016
A series of tritylated and dimethoxytritylated analogues of selected pyrimidine and purine nucleosides were synthesized and evaluated for their in vitro inhibitory activity against two important members of the genus Flavivirus in the Flaviviridae family,
Abd Kadir, Angusti, Balzarini, Beigelman, Casanova, Chatelain, De Burghgraeve, De Clercq, de La Torre, Galmarini, Greene, Guzman, Helferich, Hernández, Hough, Jordheim, Kangas, Kohli, Leyssen, Liekens, Liekens, Niles, Pathak, Pałasz, Rothan, Ruda, Saudi, Simmons, Vernekar, Whittingham, Yung, Žemlička   +31 more
core   +1 more source

DNA‐Templated 2D Heterostructures as Phototriggered Dynamic Nanohybrids: From Releasing Molecular Loads to Controlling Enzyme Biocatalytic Function

Advanced Functional Materials, EarlyView.
DNA strands are employed both as dynamic linkers and nanoscale templates for the integration of Ag2S nanoparticles on MoS2, which in turn imparted photothermal responsiveness; this feature permits the selective cargo (fluorophore, quantum dots or an enzyme) release from the MoS2 surface in response to local heat induced by light irradiation.
Kai Chen, Haosen Miao, Weiying Hong, Matteo Palma   +3 more
wiley   +1 more source

Microwave-assisted ring closure reactions: Synthesis of 8-substituted xanthine derivatives and related pyrimido- and diazepinopurinediones

Beilstein Journal of Organic Chemistry, 2006
BackgroundPoly-substituted xanthine derivatives are an important class of compounds in medicinal chemistry. Substitution at the 8-position of the purine ring is generally accessible by ring closure of a carboxamido-substituted uracil precursor.
Joachim C. Burbiel, Jörg Hockemeyer, Christa E. Müller   +2 more
doaj   +1 more source

In silico binding affinity studies of N-9 substituted 6-(4-(4-propoxyphenyl)piperazin-1-yl)-9H-purine derivatives-Target for P70-S6K1 & PI3K-δ kinases

Beni-Suef University Journal of Basic and Applied Sciences, 2018
P70-S6K1 & PI3K-δ kinases are identified to be involved in many physiological processes associated with cancer, therefore many of the inhibitors being designed to target these kinases are in clinical trials. In the current study we have exploited the N-9
Manjunath G. Sunagar, P. Aravind, Supreet Gaonkar, K.S. Devaraju, Shrinivas D. Joshi, Sheshagiri R. Dixit, B.M. Harish, Imtiyaz Ahmed M. Khazi   +7 more
doaj   +1 more source

Electron collisions with biomolecules [PDF]

, 2008
We report on results of recent studies of collisions of low-energy electrons with nucleobases and other DNA constituents. A particular focus of these studies has been the identification and characterization of resonances that play a role in electron ...
McKoy, Vincent, Winstead, Carl
core   +1 more source

Endothelium-Derived Vasoconstriction by Purines and Pyrimidines [PDF]

Circulation Research, 2008
See related article, pages 1100–1108 The article by Tolle et al1 claims to show for the first time that adenosine 5′-tetraphosphate (AP4) is released on mechanical stimulation from human microvascular endothelial cells in the perfused rat kidney and, further, that AP4 is the most potent mediator of vascular smooth muscle constriction via P2X1 ...
openaire   +2 more sources

Shape‐Controlled Guanine Self‐Assemblies for Stable and Fast‐Ion Solid–Electrolyte Interphases in Sustainable Li Metal Batteries

Advanced Functional Materials, EarlyView.
The shape of guanine self‐assemblies is tuned by introducing alkyl (G8), fluoroalkyl (G8f), and oligoether (G8g) side chains into the G moiety. The scanning tunneling microscopy results and calculations show that the presence and type of the side chain strongly affect the G self‐assembly network.
So‐Huei Kang, So‐Dam Sohn, Kyung Min Lee, Seok‐Kyu Cho, Byongkyu Lee, Ji Eun Lee, Sang‐Young Lee, Sang Kyu Kwak, Hyung‐Joon Shin, Changduk Yang   +9 more
wiley   +1 more source