Results 31 to 40 of about 1,617,490 (298)

Microwave-assisted ring closure reactions: Synthesis of 8-substituted xanthine derivatives and related pyrimido- and diazepinopurinediones

Beilstein Journal of Organic Chemistry, 2006
BackgroundPoly-substituted xanthine derivatives are an important class of compounds in medicinal chemistry. Substitution at the 8-position of the purine ring is generally accessible by ring closure of a carboxamido-substituted uracil precursor.
Joachim C. Burbiel, Jörg Hockemeyer, Christa E. Müller   +2 more
doaj   +1 more source

In silico binding affinity studies of N-9 substituted 6-(4-(4-propoxyphenyl)piperazin-1-yl)-9H-purine derivatives-Target for P70-S6K1 & PI3K-δ kinases

Beni-Suef University Journal of Basic and Applied Sciences, 2018
P70-S6K1 & PI3K-δ kinases are identified to be involved in many physiological processes associated with cancer, therefore many of the inhibitors being designed to target these kinases are in clinical trials. In the current study we have exploited the N-9
Manjunath G. Sunagar, P. Aravind, Supreet Gaonkar, K.S. Devaraju, Shrinivas D. Joshi, Sheshagiri R. Dixit, B.M. Harish, Imtiyaz Ahmed M. Khazi   +7 more
doaj   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Electrochemical Determination of Benzene Substituted Derivatives using Carbon Based Purine Electrodes through Electrochemical Impedance Spectroscopy

International Journal of Electrochemical Science, 2014
Purine nucleobases, guanine and adenine, are known electroactive compounds which get oxidized over the carbon electrodes. These compounds are found to react with benzene derivatives forming its adducts.
S. Baby Gayathri, P. Kamaraj, M. Arthanareeswari, S. Devi Kala   +3 more
doaj   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Versatile synthesis and biological evaluation of novel 3’-fluorinated purine nucleosides

Beilstein Journal of Organic Chemistry, 2015
A unified synthetic strategy accessing novel 3'-fluorinated purine nucleoside derivatives and their biological evaluation were achieved. Novel 3’-fluorinated analogues were constructed from a common 3’-deoxy-3’-fluororibofuranose intermediate.
Hang Ren, Haoyun An, Paul J. Hatala, William C. Stevens Jr, Jingchao Tao, Baicheng He   +5 more
doaj   +1 more source

Mass Spectrometry Study of New Polyamine Derivatives of Caffeine

Acta Chimica Slovenica, 2018
The mass spectrometric fragmentations of ten new 8-alkylaminocaffeine derivatives were investigated. The fragmentation pathways of new polyamine derivatives of caffeine on the basis of low and high-resolution electron ionization (EI) mass spectra were ...
Arleta Sierakowska, Beata Jasiewicz, Tomasz Pospieszny   +2 more
doaj   +1 more source

1,2,3-Triazoles as leaving groups: SNAr reactions of 2,6-bistriazolylpurines with O- and C-nucleophiles

Beilstein Journal of Organic Chemistry, 2021
A new approach was designed for the synthesis of C6-substituted 2-triazolylpurine derivatives. A series of substituted products was obtained in SNAr reactions between 2,6-bistriazolylpurine derivatives and O- and C-nucleophiles under mild conditions. The
Dace Cīrule, Irina Novosjolova, Ērika Bizdēna, Māris Turks   +3 more
doaj   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Unraveling RNA contribution to the molecular origins of bacterial surface-enhanced Raman spectroscopy (SERS) signals

Scientific Reports
Surface-enhanced Raman spectroscopy (SERS) is widely utilized in bacterial analyses, with the dominant SERS peaks attributed to purine metabolites released during sample preparation.
Jun-Yi Chien, Yong-Chun Gu, Chia-Chen Chien, Chia-Ling Chang, Ho-Wen Cheng, Shirley Wen-Yu Chiu, Yeu-Jye Nee, Hsin-Mei Tsai, Fang-Yeh Chu, Hui-Fei Tang, Yuh-Lin Wang, Chi-Hung Lin   +11 more
doaj   +1 more source