Results 31 to 40 of about 677,954 (299)

In silico binding affinity studies of N-9 substituted 6-(4-(4-propoxyphenyl)piperazin-1-yl)-9H-purine derivatives-Target for P70-S6K1 & PI3K-δ kinases

Beni-Suef University Journal of Basic and Applied Sciences, 2018
P70-S6K1 & PI3K-δ kinases are identified to be involved in many physiological processes associated with cancer, therefore many of the inhibitors being designed to target these kinases are in clinical trials. In the current study we have exploited the N-9
Manjunath G. Sunagar, P. Aravind, Supreet Gaonkar, K.S. Devaraju, Shrinivas D. Joshi, Sheshagiri R. Dixit, B.M. Harish, Imtiyaz Ahmed M. Khazi   +7 more
doaj   +1 more source

DNA‐Templated 2D Heterostructures as Phototriggered Dynamic Nanohybrids: From Releasing Molecular Loads to Controlling Enzyme Biocatalytic Function

Advanced Functional Materials, EarlyView.
DNA strands are employed both as dynamic linkers and nanoscale templates for the integration of Ag2S nanoparticles on MoS2, which in turn imparted photothermal responsiveness; this feature permits the selective cargo (fluorophore, quantum dots or an enzyme) release from the MoS2 surface in response to local heat induced by light irradiation.
Kai Chen, Haosen Miao, Weiying Hong, Matteo Palma   +3 more
wiley   +1 more source

Versatile synthesis and biological evaluation of novel 3’-fluorinated purine nucleosides

Beilstein Journal of Organic Chemistry, 2015
A unified synthetic strategy accessing novel 3'-fluorinated purine nucleoside derivatives and their biological evaluation were achieved. Novel 3’-fluorinated analogues were constructed from a common 3’-deoxy-3’-fluororibofuranose intermediate.
Hang Ren, Haoyun An, Paul J. Hatala, William C. Stevens Jr, Jingchao Tao, Baicheng He   +5 more
doaj   +1 more source

Electrochemical Determination of Benzene Substituted Derivatives using Carbon Based Purine Electrodes through Electrochemical Impedance Spectroscopy

International Journal of Electrochemical Science, 2014
Purine nucleobases, guanine and adenine, are known electroactive compounds which get oxidized over the carbon electrodes. These compounds are found to react with benzene derivatives forming its adducts.
S. Baby Gayathri, P. Kamaraj, M. Arthanareeswari, S. Devi Kala   +3 more
doaj   +1 more source

Integrating Genetics With Epidemiological Measurements Identifies Burden QTLs of Inflammatory Bowel Disease across 20 Countries

Advanced Science, EarlyView.
The burden quantitative trait locus (bQTL) analysis integrates epidemiological data from GBD study with genotype of 2 621 978 SNPs from 2414 individuals in 1000 Genomes Project across 20 countries. rs7633471 shows the strongest effect that each increase in centi‐allele frequency of the allele C associated with 10.00 decrease of age‐standardized ...
Chen Sun, Siyu Wei, Junxian Tao, Haiyan Chen, Chi Yan, Jiacheng Wang, Jing Xu, Lian Duan, Yuanbo Zhan, Yuping Zou, Ruilin Li, Linna Yuan, Wei She, Songlin Lu, Ning Wang, Qinduo Ren, Yan Guo, Yuan Xu, Chang Wang, Hongsheng Tian, Chen Zhang, Yu Dong, Guoping Tang, Zhenwei Shang, Yongshuai Jiang, Wenhua Lv, Mingming Zhang, Hongchao Lyu   +27 more
wiley   +1 more source

Chemo-Enzymatic Generation of Highly Fluorescent Nucleoside Analogs Using Purine-Nucleoside Phosphorylase

Biomolecules
Chemo-enzymatic syntheses of strongly fluorescent nucleoside analogs, potentially applicable in analytical biochemistry and cell biology are reviewed. The syntheses and properties of fluorescent ribofuranosides of several purine, 8-azapurine, and etheno ...
Alicja Stachelska-Wierzchowska, Jacek Wierzchowski   +1 more
doaj   +1 more source

Mass Spectrometry Study of New Polyamine Derivatives of Caffeine

Acta Chimica Slovenica, 2018
The mass spectrometric fragmentations of ten new 8-alkylaminocaffeine derivatives were investigated. The fragmentation pathways of new polyamine derivatives of caffeine on the basis of low and high-resolution electron ionization (EI) mass spectra were ...
Arleta Sierakowska, Beata Jasiewicz, Tomasz Pospieszny   +2 more
doaj   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Unraveling RNA contribution to the molecular origins of bacterial surface-enhanced Raman spectroscopy (SERS) signals

Scientific Reports
Surface-enhanced Raman spectroscopy (SERS) is widely utilized in bacterial analyses, with the dominant SERS peaks attributed to purine metabolites released during sample preparation.
Jun-Yi Chien, Yong-Chun Gu, Chia-Chen Chien, Chia-Ling Chang, Ho-Wen Cheng, Shirley Wen-Yu Chiu, Yeu-Jye Nee, Hsin-Mei Tsai, Fang-Yeh Chu, Hui-Fei Tang, Yuh-Lin Wang, Chi-Hung Lin   +11 more
doaj   +1 more source

New Purine Derivatives from the Marine Sponge

Natural Product Communications, 2008
Four new purine analogues (nigricines 1 – 4) have been isolated from the Indonesian marine sponge Petrosia nigricans. The structures were elucidated by extensive 2D-NMR spectroscopic experiments and mass spectrometry.
Mohamed Ashour, RuAngelie Edrada-Ebel, Rainer Ebel, Victor Wray, Rob.W.M. van Soest, Peter Proksch   +5 more
doaj   +1 more source