Results 151 to 160 of about 72,751 (304)

Human Umbilical Cord Plasma Metabolomics Uncover Potential Metabolites for Combating Aging

Aging Cell, EarlyView.
Untargeted metabolomics reveals a unique cord plasma metabolic landscape versus adult. Age‐declining cord‐specific enriched metabolites are identified as antiaging candidates, with a 5‐compound formula validated in proof‐of‐experiments to extend lifespan and healthspan in human cells and C. elegans.
JiaYu Liu, Shuai Jiang, YanYan Shen, RuiBo Wang, Zhi Jin, YanQing Cao, JinLiang Li, YanHong Liu, Qi Qi, Yue Guo, YunYing Wang, BoYang Xie, JunCheng Li, AiPing Cao, Yao Wang, ChunYan Yan, QiuYing Han, YingJie Zhu, Jing Peng, FangTing Dong, Xin Pan, XinHua He, Tao Zhou, AiLing Li, Kun He, Na Wang, WeiNa Zhang, Qing Xia   +27 more
wiley   +1 more source

Molecular variation in relation to purine metabolism [PDF]

, 1974
R. W. E. Watts
openalex   +1 more source

THE PURINE METABOLISM OF ESCHERICHIA COLI

Journal of Biological Chemistry, 1952
A L, KOCH, F W, PUTNAM, E A, EVANS
openaire   +2 more sources

A Global Metabolomic and Lipidomic Landscape of Human Plasma Across the Lifespan

Aging Cell, EarlyView.
Liu et al. provide a comprehensive analysis of dynamic plasma metabolomic and lipidomic changes in humans across the lifespan, identifying age‐specific metabolic trajectories and developing a metabolite‐based aging clock, offering insights into metabolic reprogramming and potential biomarkers for aging‐related health interventions.
Xinru Liu, Tingting Liang, Rui Zhao, Mingming Zhu, Beibei Huang, Xiaobi Huang, Fang Ni   +6 more
wiley   +1 more source

Inhibition of Purine Metabolism Promotes the Differentiation of Neuroblastoma Driven by MYCN. [PDF]

Cancer Med
Jiang Y, Xiao H, Yang Y, Chen G, Zhang Y, Wu X, Zhang Q, Huang Q, Gao H, Han Y, Zhang A, Jiang D, Zheng L, Li Y, Gao Y.   +14 more
europepmc   +1 more source

AB0872 Diagnostic efficiency of determining the purine metabolism enzymes activity in the differentiation of gout [PDF]

, 2017
E. E. Mozgovaya, А. С. Трофименко, С. А. Бедина, I.А. Zborovskaya   +3 more
openalex   +1 more source

cdh23 affects congenital hearing loss through regulating purine metabolism

, 2023
Yang Shu, Bing-Lin Xie, Xiao‐Ping Dong, Ling-Xiang Wang, Ganghua Zhu, Tian Wang, Weijing Wu, Ruosha Lai, Tao Rong, Min‐Xin Guan, Fangyi Chen, Donghui Tan, Zhong Liang Deng, Huaping Xie, Yong Zeng, Zian Xiao, Dinghua Xie   +16 more
openalex   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Purine Metabolism Pathway Influence on Running Capacity in Rats. [PDF]

Metabolites
Chen D, Biney CN, Wang Q, Cai M, Cheng S, Chen W, Zhang J, Zhao J, Zhang Y, Zhang W.   +9 more
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source