Results 151 to 160 of about 1,297,457 (342)

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro   +5 more
wiley   +1 more source

Anti‐Cancer Potential of Copper‐NTB Complex via Damaging Cellular Organelles and Apoptosis in Triple‐Negative Breast Cancer Therapy

open access: yesNano Select, EarlyView.
Summarizes the dose‐dependent anti‐cancer activity of copper(Cu)‐tris((1H‐benzo[d]imidazol‐2‐yl)methyl)amine (NTB) or [Cu(NTB)(OH2)](ClO4)2 or Cu‐NTB complex against MDA‐MB‐231 breast cancer cells via apoptosis, DNA damage, lysosomal membrane permeabilization, and mitochondrial dysfunction.
Sri Renukadevi Balusamy   +9 more
wiley   +1 more source

Microbiota diversity and differences in the respiratory tract of children with pneumonia

open access: yesPediatric Investigation, EarlyView.
Differences in microbial communities in the upper and lower respiratory tract in patients with pneumonia were investigated in this study by sequencing the 16S rRNA genes in pharyngeal swabs and alveolar lavage fluid. Forty‐three subjects were enrolled in the study, and one upper and one lower respiratory tract sample were collected from each subject ...
Dandan Ge   +4 more
wiley   +1 more source

Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Kalpana Panneerselvam   +12 more
wiley   +1 more source

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