Results 141 to 150 of about 971,178 (247)

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Deoxyguanosine kinase deficiency couples purine metabolism to innate immune activation and lipid accumulation in hepatocytes. [PDF]

Front Immunol
Corey M, Rayadurgam M, Vatanmakanian M, Gibbons A, Altbaum C, Jung J, Reddy N, Saminathan P, Kakugawa K, Sharma S.   +9 more
europepmc   +1 more source

Adss1–HDAC3 Interaction: A Novel Mechanism for Epigenetic Regulation of Metabolism in Adipose Tissue

iNew Medicine, EarlyView.
ABSTRACT Obesity and its related metabolic disorders have emerged as global public health challenges with underlying mechanisms involving an imbalance between energy storage and expenditure in the adipose tissue. In recent years, with the deepening research on adipose tissue metabolism, the cross talk between metabolic enzymes and epigenetic regulation
Jiarui Zhao, Jingjing Sun, Yan Lu, Ying Yang   +3 more
wiley   +1 more source

Kiss and spit metabolomics highlight the role of host purine metabolism during pathogen infection. [PDF]

mSphere
Gallego-Lopez GM, Olson WJ, Tibabuzo-Perdomo AM, Stevenson D, Amador-Noguez D, Lawrence G, Leahy JW, Contreras Guzman E, Skala MC, Knoll LJ.   +9 more
europepmc   +1 more source

Metabolic feature profiling and metabolic vulnerability in acute lymphoblastic leukemia

Interdisciplinary Medicine, EarlyView.
For the first time, our study develops a novel metabolic classification and subtyping program, metabolic reprogramming‐based classifier for acute lymphoblastic leukemia, using internal PDT‐ALL‐2016 and external cohorts, which dissects metabolic profiling, clinical outcome, and therapeutic vulnerability for precision metabolic intervention in ALL ...
Xiaojie Liang, Zihong Cai, Bingqing Tang, Zicong Huang, Baiwei Luo, Bingyu Lin, Yunong Yang, Zhihao Jin, Xiaoqing Li, Xiuli Xu, Yeling Deng, Chaoran Lin, Liang Wang, Hongsheng Zhou   +13 more
wiley   +1 more source

The Role of Serum Uric Acid in the Prediction of Type 2 Diabetes Mellitus: Tehran Lipid and Glucose Study

Journal of Clinical Laboratory Analysis, EarlyView.
This study aimed to examine the association between serum uric acid and incident type 2 diabetes mellitus. The study included 5719 subjects (2588 men) aged ≥ 30 years without T2DM at baseline. Multivariate Cox proportional hazard analyses were applied using SUA as continuous and categorical variables. Subjects followed up during a median follow‐up of 8.
Nahid Kord, Samaneh Asgari, Maryam Tohidi, Somayeh Hosseinpour‐Niazi, Fereidoun Azizi, Farzad Hadaegh   +5 more
wiley   +1 more source

Raspberry aqueous extract ameliorates MAFLD in mice by regulating gut microbiota and purine metabolism. [PDF]

Front Nutr
Gao Y, Liu N, Wei H, Sun T, Xu F, Chen L, Qiu J, Dou X.   +7 more
europepmc   +1 more source

2,6-Bis-Triazolyl Purine Deoxyribo-Nucleosides and Their Reactions with N-Nucleophiles

New 2,6-bis-triazolyl derivatives of purine deoxyribo-nucleosides have been synthesized and their reactions with piperidine and pyrrolidine have been ...
Cīrule, Dace, Bizdēna, Ērika, Novosjolova, Irina, Ozols, Kristers   +3 more
core  

Shared genetic and molecular architecture between neurodevelopmental disorders and type 1 diabetes

Journal of Intelligent Medicine, EarlyView.
Abstract Epidemiological and clinical studies have suggested possible associations between type 1 diabetes (T1D) and neurodevelopmental disorders (NDDs), but these relationships remain inconsistent across disorders and populations. To clarify whether such mixed findings, we investigated the genetic architecture linking T1D with autism spectrum disorder
Jingxuan Zhang, Zhentao Zhou, Lirong Zhu, Wei Liu   +3 more
wiley   +1 more source

Changes in Purine Metabolism During Differentiation of Dopamine Neurons from Human Induced Pluripotent Stem Cells. [PDF]

Cell Mol Neurobiol
Grychowski L, Seifar F, Ozel E, Thite A, Sutcliffe DJ, Dinasarapu AR, Hess EJ, Jinnah HA.   +7 more
europepmc   +1 more source