Results 281 to 290 of about 1,297,457 (342)
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Journal of Medicinal Chemistry, 2022
The curative effect of sorafenib in hepatocellular carcinoma (HCC) is limited and sorafenib resistance remains a major obstacle for HCC. To overcome this obstacle, a new photoactive sorafenib-Ru(II) complex Ru-Sora has been designed. Upon irradiation (λ =
Yidan Lai +4 more
semanticscholar +1 more source
The curative effect of sorafenib in hepatocellular carcinoma (HCC) is limited and sorafenib resistance remains a major obstacle for HCC. To overcome this obstacle, a new photoactive sorafenib-Ru(II) complex Ru-Sora has been designed. Upon irradiation (λ =
Yidan Lai +4 more
semanticscholar +1 more source
The Role of Probiotics in Purine Metabolism, Hyperuricemia and Gout: Mechanisms and Interventions
Food reviews international (Print), 2021Hyperuricemia and gout are metabolic diseases characterized with high serum urate and impact human health significantly. Although some drugs have been developed to treat gout, hyperuricemia represents a substantial health problem.
Armachius James +3 more
semanticscholar +1 more source
New insights into purine metabolism in metabolic diseases: role of xanthine oxidoreductase activity.
American Journal of Physiology. Endocrinology and Metabolism, 2020Xanthine oxidoreductase (XOR) consists of two different forms, xanthine dehydrogenase (XDH) and xanthine oxidase (XO), and is a rate-limiting enzyme of uric acid production from hypoxanthine and xanthine. Uric acid is the end-product of purine metabolism
M. Furuhashi
semanticscholar +1 more source
Environmental Science and Technology, 2020
Parabens are widely used as common preservatives in pharmaceutical and cosmetic industries. Exposure to parabens has been found to be associated with metabolic alterations of human and the increased risk of metabolic disease, such as diabetes.
Hongzhi Zhao +9 more
semanticscholar +1 more source
Parabens are widely used as common preservatives in pharmaceutical and cosmetic industries. Exposure to parabens has been found to be associated with metabolic alterations of human and the increased risk of metabolic disease, such as diabetes.
Hongzhi Zhao +9 more
semanticscholar +1 more source
FRUCTOSE AND PURINE METABOLISM
Acta Medica Scandinavica, 1972Abstract.The interactions between fructose and purine metabolism are reviewed. Hyperuricemia and increased production of uric acid after fructose administration have been documented in man as well as in the rat. These effects appear to be dependent on the rapid phosphorylation of fructose, mainly in the liver.
Pekka H. Mäenpää +2 more
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Purine Metabolism in Trypanosomatids*
The Journal of Protozoology, 1979SYNOPSIS. Purine nucleotide biosynthesis was studied in culture forms of Trypanosoma cruzi strain Y, Crithidia deanei (a reduviid trypanosomatid with an endosymbiote) and an aposymbiotic strain of C. deanei (obtained by curing C. deanei with chloramphenicol).
Isaac Roitman +4 more
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Biochemical Society Transactions, 1981
Abstract The inherited disorders of purine metabolism associated with renal disease are listed in Table 24.1. They are the sole cause of only a small proportion of all renal disease and are therefore best considered as part of the overall problem of purine, especially uric acid metabolism-related renal disease.
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Abstract The inherited disorders of purine metabolism associated with renal disease are listed in Table 24.1. They are the sole cause of only a small proportion of all renal disease and are therefore best considered as part of the overall problem of purine, especially uric acid metabolism-related renal disease.
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Expert Opinion on Drug Metabolism & Toxicology, 2020
Objectives Rifampin (RIF), isoniazid (INH) and pyrazinamide (PZA) are essential components of the short-term first-line anti-tuberculosis (anti-TB) chemotherapy regimen and can cause hepatotoxicity.
Linsheng Liu +7 more
semanticscholar +1 more source
Objectives Rifampin (RIF), isoniazid (INH) and pyrazinamide (PZA) are essential components of the short-term first-line anti-tuberculosis (anti-TB) chemotherapy regimen and can cause hepatotoxicity.
Linsheng Liu +7 more
semanticscholar +1 more source
Journal of Proteome Research, 2020
Chronic mountain sickness (CMS) is a high-altitude complication with high rates of morbidity and mortality. CMS is characterized by high-altitude polycythemia (HAPC) and high-altitude pulmonary hypertension (HAPH).
Xiaojian Gao +9 more
semanticscholar +1 more source
Chronic mountain sickness (CMS) is a high-altitude complication with high rates of morbidity and mortality. CMS is characterized by high-altitude polycythemia (HAPC) and high-altitude pulmonary hypertension (HAPH).
Xiaojian Gao +9 more
semanticscholar +1 more source
Metabolism of Purines and Pyrimidines
Annual Review of Biochemistry, 1956The emphasis of recent reviews on structural aspects of nucleic acid chem istry and the substantial achievement represented by the publications of the past year on the metabolism of purine and pyrimidine nucleotides has led to the selection of enzymic reactions operative in the synthesis of these com pounds as the principal subject of this review ...
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