Brain and Behavior, Volume 15, Issue 11, November 2025.GI and ND GWAS and blood eQTL data were analyzed using LDSC, HDL, LAVA, GPA, PLACO, FUMA, MAGMA, SMR, HEIDI, and two‐sample MR to assess genetic correlations, pleiotropy, functional annotation, shared gene expression, and causal relationships. ABSTRACT Background This study investigates the shared genetic basis between gastrointestinal (GI) diseases ...
Yan Jiang +3 more
wiley +1 more source
Cellular response to purinergic agonists.
, 2012 Cellular response to purinergic agonists.
Duane J. Oswald (136470) +6 more
core +1 more source
Release of ATP in the ventral medulla during hypoxia in rats: role in hypoxic ventilatory response [PDF]
, 2005 P2X2 receptor subunits of the ATP-gated ion channels are expressed by physiologically identified respiratory neurons in the ventral respiratory column, implicating ATP in the control of respiratory activity.
Spyer, K. Michael +7 more
core +1 more source
Investigations on neuropeptide Y and histamine receptors by fluorescence-based and radiochemical methods [PDF]
, 2011 In the last three decades, a large amount of experimental data (for example Förster resonance energy transfer (FRET) at fluorescently labelled receptors) supported the hypothesis of the dimerization of G-protein-coupled receptors (GPCR), including ...
Lopuch, Miroslaw
core +1 more source
P2Y₂ Nucleotide Receptors Expressed Heterologously in Sympathetic Neurons Inhibit Both N-Type Ca²⁺ and M-Type K⁺ Currents [PDF]
, 1998 The P2Y₂ receptor is a uridine/adenosine triphosphate (UTP/ATP)-sensitive G-protein-linked nucleotide receptor that previously has been reported to stimulate the phosphoinositide signaling pathway.
Webb, TE +3 more
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Molecular pharmacology of an insect GABA receptor [PDF]
, 2010 Cys-loop receptors are ligand-gated ion channels that are involved in fast synaptic neurotransmission in the central and peripheral nervous system. The Cys-loop receptor RDL (‘resistant to dieldrin’) is a GABA-gated chloride channel from Drosophila ...
core +2 more sources
Emerging key roles for P2X receptors in the kidney [PDF]
, 2013 P2X ionotropic non-selective cation channels are expressed throughout the kidney and are activated in a paracrine or autocrine manner following the binding of extracellular ATP and related extracellular nucleotides.
Peppiatt-Wildman, Claire M. +10 more
core +1 more source
Synthesis and Structure-Activity Relationships of Pyridoxal-6-arylazo-5'-phosphate and Phosphonate Derivatives as P2 Receptor Antagonists. [PDF]
, 1998 Novel analogs of the P2 receptor antagonist pyridoxal-5'-phosphate-6-phenylazo-2',4'-disulfonate (PPADS) were synthesized. Modifications were made through functional group substitution on the sulfophenyl ring and at the phosphate moiety through the ...
B. F. King +42 more
core +1 more source
Activation of Purinergic Receptor Subtypes Modulates Odor Sensitivity
, 2003 Purinergic nucleotides, including ATP and adenosine, are important neuromodulators of peripheral auditory and visual sensory systems (Thorne and Housley, 1996).
Pengcheng Han +4 more
core +2 more sources
The P2X receptor mediated regulation of inhibitory synaptic transmission [PDF]
In the central nervous system ATP can be released by neurons and glial cells through similar pathways as other neurotransmitters. Extracellular ATP targets P2X purinoreceptors, causing an influx of Ca2+ ions which transmit very important messages for ...
Andrew-Adiamah, Jemma
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