Results 91 to 100 of about 4,496 (116)

E. B. Hershberg Award: Taming Inflammation by Tuning Purinergic Signaling. [PDF]

Acc Chem Res
Jacobson KA.
europepmc   +1 more source

Hemostasis-Sparing Antiplatelet Therapy: Current Concepts and Emerging Targets in Arterial Thrombosis. [PDF]

Biomol Ther (Seoul)
Park JW, Oh EB, Chang TS.
europepmc   +1 more source

Temporal mRNA Expression of Purinergic P2 Receptors in the Brain Following Cerebral Ischemia and Reperfusion: Similarities and Distinct Variations Between Rats and Mice. [PDF]

Int J Mol Sci
Challa SR, Levingston H, Fornal CA, Baker IM, Boston J, Shanthappa N, Unnam P, Klopfenstein JD, Veeravalli KK.   +8 more
europepmc   +1 more source

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Antagonists and the purinergic nerve hypothesis: 2,2′-pyridylisatogen tosylate (PIT), an allosteric modulator of P2Y receptors. A retrospective on a quarter century of progress

Journal of the Autonomic Nervous System, 2000
2,2'-Pyridylisatogen tosylate (PIT) is a selective antagonist of P2Y responses in smooth muscle and does not antagonise the effects of adenosine. Responses to purinergic nerve stimulation are resistant to PIT. PIT is an allosteric modulator of responses to ATP in recombinant P2Y(1) receptors expressed in Xenopus oocytes with potentiation of ATP at low ...
Michael Spedding, A Markham, D F Weetman   +2 more
exaly   +3 more sources

Novel Antagonists Acting at the P2Y₁ Purinergic Receptor:  Synthesis and Conformational Analysis Using Potentiometric and Nuclear Magnetic Resonance Titration Techniques

Journal of Medicinal Chemistry, 2002
The human P2Y(1) receptor is widely distributed in many tissues and has a classical structure of a G protein-coupled receptor. Activated by adenosine-5'-diphosphate (ADP), this receptor is essential for platelet aggregation. In the present paper, we describe the synthesis of novel P2Y(1) antagonists that could be of interest at least as tools to define
Raboisson, Pierre, Baurand, Anthony, Cazenave, Jean-Pierre, Gachet, Christian, Retat, Myriam, Spiess, Bernard, Bourguignon, Jean-Jacques   +6 more
openaire   +3 more sources

Carba‐nucleosides as Potent Antagonists of the Adenosine 5′‐Diphosphate (ADP) Purinergic Receptor (P2Y₁₂) on Human Platelets

ChemMedChem, 2008
Whereas the activation and aggregation of blood platelets are crucial to normal hemostasis, this ensemble is also a key factor in serious cardiovascular disorders, such as myocardial infarction, unstable angina, transient ischemic attack, stroke, peripheral arterial disease, and artherosclerosis.
Hong, Ye, Cailin, Chen, Han-Cheng, Zhang, Barbara, Haertlein, Tom J, Parry, Bruce P, Damiano, Bruce E, Maryanoff   +6 more
openaire   +2 more sources

Synthesis, characterization and biological evaluation of indomethacin derived thioureas as purinergic (P2Y1, P2Y2, P2Y4, and P2Y6) receptor antagonists

Bioorganic Chemistry, 2021
Anwar Ul-Hamid, Aamer Saeed, Jamshed Iqbal   +2 more
exaly  

Pregabalin inhibits purinergic P2Y2 receptor and TRPV4 to suppress astrocyte activation and to relieve neuropathic pain

European Journal of Pharmacology, 2023
Shouwei Yue
exaly  

Control of Macrophage Inflammation by P2Y Purinergic Receptors

Cells, 2021
Martin Thurnher, Dominik Klaver, Thurnher Martin   +2 more
exaly