Results 191 to 200 of about 53,976 (309)

RESEARCHES ON PURINES. XVI

, 1915
Carl O. Johns, Byron M. Hendrix
openalex   +1 more source

Assessing gout risk associated with GLP‐1 therapy in obese patients with type 2 diabetes: A retrospective cohort study

Rheumatology &Autoimmunity, EarlyView.
Justin Riley Lam, Emmanuel Otabor, Laith Alomari, Maxim Barnett, Bal Subedi, Het Hirpara, Freya Thummar   +6 more
wiley   +1 more source

Polypharmacy in mice disrupts left ventricular function and structure and promotes proteome reorganisation in an age‐ and sex‐specific fashion

British Journal of Pharmacology, EarlyView.
Background and Purpose Most older people use polypharmacy (≥5 medications), particularly those with cardiovascular disease. The effects of polypharmacy on the cardiovascular system are not well described. We examined the effect of a chronic polypharmacy regimen on left ventricular (LV) function, structure and proteome in young and old mice of both ...
Trang Tran, Kevin Winardi, Scott P. Levick, Alexander Widiapradja, Gizem Gemikonakli, Susan E. Howlett, Matthew J. McKay, Mark P. Molloy, John Mach, Sarah N. Hilmer   +9 more
wiley   +1 more source

PURINE METABOLISM IN BACTERIA

, 1955
Samuel H. Love, Joseph S. Gots
openalex   +1 more source

Klebsiella pneumoniae contributes to altered cytotoxicity of thiopurines in vitro: Possible implications of biotransformation and bacterial metabolism

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Thiopurines are used in paediatric inflammatory bowel disease (IBD), but some patients do not respond. Because the gut microbiota influences drug efficacy and IBD‐patient microbiota presents increased bacterial abundance, we investigated the impact of candidate Enterobacteriaceae on drug cytotoxicity, metabolism and ...
Martina Franzin, Cristina Lagatolla, Sofia Sindici Forgiarini, Mathias Haag, Sylvia Karin Neef, Manola Comar, Elke Schaeffeler, Barbara Bellich, Matteo Bramuzzo, Giuliana Decorti, Marianna Lucafò, Ute Hofmann, Matthias Schwab, Gabriele Stocco   +13 more
wiley   +1 more source

Untargeted Metabolomics and Liquid Biopsy Investigation of Circulating Biomarkers in Soft Tissue Sarcoma. [PDF]

Cancers (Basel)
Grasso D, Marzocchi B, Scoccianti G, Palchetti I, Campanacci DA, Antonuzzo L, Scolari F, Pillozzi S, Bernini A.   +8 more
europepmc   +1 more source

THE PURINE AND PYRIMIDINE COMPOSITION OF THE TOBACCO MOSAIC VIRUS AND THE HOLMES MASKED STRAIN

, 1954
William D. Cooper, Hubert S. Loring
openalex   +1 more source

Pharmacological evaluation of non‐nucleotide purine derivatives as P2X7 antagonists for the treatment of neuroinflammation in traumatic brain injury

British Journal of Pharmacology, EarlyView.
Background and purpose Traumatic brain injury (TBI) is considered to be a leading cause of mortality and disability worldwide. After TBI, innate immunity is rapidly activated in response to damage‐associated molecular patterns, such as ATP release, recognised by P2X7 receptors.
Inés Valencia, Andrea Pastor‐Martínez, Céline Decouty‐Pérez, Ana Belen Lopez‐Rodriguez, María Álvarez‐Rubal, Eva Ramos, Francesco Calzaferri, Jorge Zamorano‐Fernández, Javier Giner‐García, Alexis J. Palpán‐Flores, Víctor Rodríguez‐Domínguez, Javier Rodríguez de Cía, Borja J. Hernández‐García, Alejandro Romero, Cristóbal de los Ríos, Javier Egea   +15 more
wiley   +1 more source

Exploring the Impact of the Gut Microbiota/REV-ERBα/NF-κB Axis on the Circadian Rhythmicity of Gout Flares from a Chronobiological Perspective. [PDF]

J Inflamm Res
Wang H, Liu M, Xie C, Zhao L, Wang H.
europepmc   +1 more source

THE UTILIZATION OF PURINE NUCLEOSIDES FOR NUCLEIC ACID SYNTHESIS IN THE RAT

, 1952
Bertram A. Lowy, John Davoll, George Bosworth Brown   +2 more
openalex   +1 more source