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Microorganisms, 2017 Excessive intake of purine-rich foods elevates serum levels of uric acid. Animal and fish meats contain high amounts of inosine and its related purines, and the reduction of taking those purines is crucial for the improvement of serum uric acid levels ...
Hiroshi Kano
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Photochemistry and Photobiology, 1988
Abstract— DNA purine modifications by ultraviolet irradiation have not been as extensively studied as those of pyrimidines. However, a number of such reactions have been identified. These include photochemical addition of amino acids, photoalkylation by alcohols, amines and other compounds, photochemical activation of procarcinogens to mutagenic ...
N J, Duker, P E, Gallagher
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Abstract— DNA purine modifications by ultraviolet irradiation have not been as extensively studied as those of pyrimidines. However, a number of such reactions have been identified. These include photochemical addition of amino acids, photoalkylation by alcohols, amines and other compounds, photochemical activation of procarcinogens to mutagenic ...
N J, Duker, P E, Gallagher
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Neuroscience Letters, 2010 This study analyzes the relationship between extracellular purines and pain perception in humans. Cerebrospinal fluid (CSF) levels of purines and their metabolites were compared between patients displaying acute and/or chronic pain syndromes and control ...
André P Schmidt +2 more
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Feedback Control of Purine Biosynthesis by Purine Ribonucleotides
Nature, 1959IN recent years a number of biosynthetic sequences have been shown to be regulated by feedback mechanisms, which have been of two general types, the first involving regulation of the activity of an enzyme by an inhibitory effect of an end-product1,2, the second involving regulation of the rate of synthesis of an enzyme by negative-induction, or ...
J B, WYNGAARDEN, D M, ASHTON
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New England Journal of Medicine, 1976
To delineate the normal function of purine nucleoside phosphorylase and to understand the pathogenesis of the immune dysfunction associated with deficiency of this enzyme, we studied purine metabolism in a patient deficient in purine nucleoside phosphorylase, her erythrocytes and cultured fibroblasts.
A, Cohen +3 more
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To delineate the normal function of purine nucleoside phosphorylase and to understand the pathogenesis of the immune dysfunction associated with deficiency of this enzyme, we studied purine metabolism in a patient deficient in purine nucleoside phosphorylase, her erythrocytes and cultured fibroblasts.
A, Cohen +3 more
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Protonation-deprotonation of purines and purine nucleosides
Journal of Molecular Structure: THEOCHEM, 1989Abstract The protonation of purines and purine nucleosides at N7 and the HC8 acidity of the cations have been explored by semi-empirical and ab initio MO ...
Donald W. Boerth, Pradip K. Bhowmik
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New England Journal of Medicine, 1970
"The biochemistry of uric acid and its relation to gout" was recently (1963) reviewed in a series of articles that appeared in the Medical Progress section of the Journal.1 In this series the bioch...
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"The biochemistry of uric acid and its relation to gout" was recently (1963) reviewed in a series of articles that appeared in the Medical Progress section of the Journal.1 In this series the bioch...
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Biochemical Society Transactions, 1981
Abstract The inherited disorders of purine metabolism associated with renal disease are listed in Table 24.1. They are the sole cause of only a small proportion of all renal disease and are therefore best considered as part of the overall problem of purine, especially uric acid metabolism-related renal disease.
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Abstract The inherited disorders of purine metabolism associated with renal disease are listed in Table 24.1. They are the sole cause of only a small proportion of all renal disease and are therefore best considered as part of the overall problem of purine, especially uric acid metabolism-related renal disease.
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3 Purine, Purine Nucleoside, and Purine Nucleotide Aminohydrolases
1971Publisher Summary This chapter discusses the chemical significance of adenosine aminohydrolase, 5′-adenylic acid aminohydrolase, adenine nucleoside, nucleotide aminohydrolase, guanine aminohydrolase, and guanosine aminohydrolase. The partially purified adenine aminohydrolase from Azotobacter vinelandii catalyzes the anaerobic conversion of adenine ...
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2003
The activation of adenosine A1, A2 andA3 receptors can protect neurones against damage generated by mechanical or hypoxic/ischaemic insults as well as excitotoxins. A1 receptors are probably effective by suppressing transmitter release and producing neuronal hyperpolarisation.
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The activation of adenosine A1, A2 andA3 receptors can protect neurones against damage generated by mechanical or hypoxic/ischaemic insults as well as excitotoxins. A1 receptors are probably effective by suppressing transmitter release and producing neuronal hyperpolarisation.
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