Results 261 to 270 of about 10,727,728 (294)
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Sodium channels in cardiac Purkinje cells
Experientia, 1987Sodium (Na+) currents are responsible for excitation and conduction in most cardiac cells, but their study has been hampered by the lack of a satisfactory method for voltage clamp. We report a new method for low resistance access to single freshly isolated canine cardiac Purkinje cells that permits good control of voltage and intracellular ionic ...
H A, Fozzard +4 more
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Purkinje Cell Migration and Differentiation
2013The Purkinje cell is the pivotal element of the cerebellar network, which integrates distinct extracerebellar inputs and generates the ultimate cortical output to be conveyed to the deep cerebellar nuclei. During development, the adult Purkinje cell phenotype is acquired through a complex sequence of ontogenetic processes, including migration from the ...
Sotelo C, ROSSI, Ferdinando
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Purkinje cell activity during motor learning
Brain Research, 1977Monkeys were trained to grasp a handle and move it in a horizontal arc to a central position by flexing or extending the wrist. A torque motor applied forces to the handle that switched at random intervals to alternately load flexor and extensor muscles. At each load switch, the handle was displaced transiently from the central position, and then moved
P F, Gilbert, W T, Thach
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Heterotopic Purkinje cells in ataxia‐telangiectasia
Neuropathology, 2011Ataxia‐telangiectasia (A‐T) is a heritable disorder of cerebellar ataxia and oculocutaneous telangiectasias caused by mutation of the ATM gene. The most prominent and consistent neuropathologic finding in the disorder is cerebellar cortical degeneration involving significant loss of granule and Purkinje cells.
Alexander R, Bottini +3 more
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Cardiovascular Engineering and Technology, 2020
The objective of this study was to reprogram human adipogenic mesenchymal stem cells (hADMSCs) to form Purkinje cells and to use the reprogrammed Purkinje cells to bioprint Purkinje networks.hADMSCs were reprogrammed to form Purkinje cells using a multi-step process using transcription factors ETS2 and MESP1 to first form cardiac progenitor stem cells ...
Evan P, Tracy +5 more
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The objective of this study was to reprogram human adipogenic mesenchymal stem cells (hADMSCs) to form Purkinje cells and to use the reprogrammed Purkinje cells to bioprint Purkinje networks.hADMSCs were reprogrammed to form Purkinje cells using a multi-step process using transcription factors ETS2 and MESP1 to first form cardiac progenitor stem cells ...
Evan P, Tracy +5 more
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Axonal abnormalities in cerebellar Purkinje cells of the ?hyperspiny Purkinje cell? mutant mouse
Journal of Neurocytology, 1990The hyperspiny Purkinje cell (hpc) is a murine, autosomal recessive mutation affecting cerebellar Purkinje cells. Axonal abnormalities in these neurons have been revealed by selective silver impregnation, specific immunohistochemical staining and electron microscopy.
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2000
Abstract Jan Evangelista Purkinje (Purkyne) was born in 1787, in the castle of Libochovice, Bohemia, where his father acted as the estate manager. He received his first formal education at the Gymnasium connected to the monastery of the Fratres piarum scholarum, in Mikulov, South Moravia, and later joined this order. After completing his
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Abstract Jan Evangelista Purkinje (Purkyne) was born in 1787, in the castle of Libochovice, Bohemia, where his father acted as the estate manager. He received his first formal education at the Gymnasium connected to the monastery of the Fratres piarum scholarum, in Mikulov, South Moravia, and later joined this order. After completing his
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Excitatory synaptic currents in Purkinje cells
Proceedings of the Royal Society of London. Series B: Biological Sciences, 1990The N-methyl-D-aspartate (NMDA) and non-NMDA classes of glutamate receptor combine in many regions of the central nervous system to form a dual-component excitatory postsynaptic current. Non-NMDA receptors mediate synaptic transmission at the resting potential, whereas NMDA receptors contribute during periods of postsynaptic depolarization and play a ...
Perkel, DJ +3 more
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1992
We present a mathematical/computer model of a Purkinje cell. The model is a binary dendritic tree of Rall compartments connected to trunk, soma and then Hodgkin-Huxley axon. We perform studies of the model for different parameters, especially those provided by Shelton, and Pellionisz and Linas.
E. K. Blum, Xin Wang
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We present a mathematical/computer model of a Purkinje cell. The model is a binary dendritic tree of Rall compartments connected to trunk, soma and then Hodgkin-Huxley axon. We perform studies of the model for different parameters, especially those provided by Shelton, and Pellionisz and Linas.
E. K. Blum, Xin Wang
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Dynamic Synchronization of Purkinje Cell Simple Spikes
Journal of Neurophysiology, 2006Purkinje cells (PCs) integrate all computations performed in the cerebellar cortex to inhibit neurons in the deep cerebellar nuclei (DCN). Simple spikes recorded in vivo from pairs of PCs separated by <100 μm are known to be synchronized with a sharp peak riding on a broad peak, but the significance of this finding is unclear.
Shin, Soon-Lim, De Schutter, Erik
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