Results 181 to 190 of about 159,015 (286)

Prime editing links the split integrated stress response to pathogenic eIF2B mutations and white matter degeneration. [PDF]

Cell Death Dis
Scagliola A, Miluzio A, Pauselli M, Ceci M, Biffo S, Ricciardi S.   +5 more
europepmc   +1 more source

Xanthatin Targets CISD1 to Drive Ferroptosis and Mitophagy as a Dual Anticancer Strategy in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer has a poor prognosis. Xanthatin directly targets and degrades CISD1, triggering ferroptosis through iron dysregulation. The concurrently activated mitophagy synergistically amplifies ferroptotic cell death. Xanthatin also demonstrates potent in vivo anti‐tumor efficacy with minimal toxicity, highlighting its therapeutic ...
Qinwen Liu, Haojie Chen, Xiang Li, Jingxin Liu, Yiwen Li, Zhenyi Shi, Shenshen Guo, Qingfeng Du, Aiping Lu, Daogang Guan   +9 more
wiley   +1 more source

Discovery, delineation, and therapeutic targeting of a hyper-translation pathway driving cytokine release syndrome. [PDF]

Cell Rep Med
Liu X, Li J, Zhang Y, Liu Y, Wang C, Wang Y, Liu Y, Yang Y, Su Y, Lu Y, Wang W, Fu YX, Lin X, Pan D, Han W, Hu X.   +15 more
europepmc   +1 more source

NIPAL1 Drives a Metabolic‐Epigenetic Feedback Loop to Promote Lactate‐Mediated Immune Evasion in Esophageal Cancer

Advanced Science, EarlyView.
The study identifies a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma that promotes glycolysis, lactate accumulation, and H3K18 histone lactylation, forming a self‐sustaining loop that suppresses CD8+ T cell immunity.
Ri‐Xin Chen, Xiao‐Dan Ma, Shui‐Dan Xu, Ao‐Tian Mo, Min‐Hua Deng, Jun‐Han Wu, Wei‐Tao Zhuang, Jin‐Ling Duan, Shu‐Huan Xie, Jin‐Long Lin, Peng Lin, Ji‐Ming Tang, Hai‐Yu Zhou, Xiao‐Song Ben, Gui‐Bin Qiao, Dan Xie   +15 more
wiley   +1 more source

The Establishment of Asian Black Bear (<i>Ursus thibetanus</i>) Fibroblast Cell Line. [PDF]

Animals (Basel)
Hu Y, Song W, Zhang L, Yuan L, Jin Y.
europepmc   +1 more source

New Ways of Thinking about Proteinuria and Progression of Renal Damage [PDF]

, 2010
Turner, Neil, Zhou, Y. S.
core   +1 more source

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

Co-translational determination of quaternary structures in chaperone factories. [PDF]

Nat Commun
Philippe M, Salloum S, Slimani F, Normanno D, Barbosa I, Chassé H, Robert MC, Urbach S, Imbert J, Séveno M, George S, Le Hir H, Boulon S, Verheggen C, Bertrand E.   +14 more
europepmc   +1 more source

A stable but reversible integrated surrogate reporter for assaying CRISPR/Cas9-stimulated homology-directed repair [PDF]

, 2017
Blanc, Valerie, Connelly, Jon P, Davidson, Nicholas O, Liao, Grace, Madison, Blair B, Pritchard, Thomas, Pruett-Miller, Shondra M, Wen, Yahong, Zhao, Ting-Ting   +8 more
core   +2 more sources

NUDT21 Drives T‐Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

Advanced Science, EarlyView.
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu, Jianwei Wang, Zhiheng Li, Qi Ji, Hui Zhang, Qinyi Zhang, Senlin Zhang, Juanjuan Yu, Yanfang Tao, Yijun Wu, Chunxia Shi, Zong Zai, Zimu Zhang, Yizhen Li, Zhenjiang Bai, Shaoyan Hu, Jian Pan, Yang Yang, Shuiyan Wu   +18 more
wiley   +1 more source