Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Psychometric properties of the purpose in life scale in Peruvian university students. [PDF]
Front PsycholVilca-Pareja V +3 more
europepmc +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Meaningful Prospective Work drives Purpose in Life: The Role of Future Work Self
Having meaningful work is a shared aspiration for both experienced workers and young adults entering the job market, as meaningful work ensures several important outcomes such as psychological well-being.
Milani Giulia +2 more
core
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Purpose in life and mortality: A meta-analysis of the published literature and individual-participant data of 488,765 participants followed for up to 32 years. [PDF]
Psychol MedSutin A +7 more
europepmc +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Contracting in the UK NHS: purpose, process and policy [PDF]
Contracting has played a central role in the NHS reforms as the principal mechanism by which resources are transferred from purchasers to providers. The nature, process and role of contracting are traced by examining the development of government policy ...
Brian Ferguson +2 more
core
Religious Morality in Education for Serving the Purpose of Our Life
Modern education follows a secular framework in its structure, content, and values, prioritizing material well-being based on secular ethics and the belief that "a hungry man is an angry man." Within this perspective, religion is confined to theology and
Aman Uddin Muzahid , Dr. Mohammad +2 more
core +1 more source
The longitudinal relation between purpose in life and accelerometer-measured physical activity. [PDF]
Ment Health Phys ActSutin AR +4 more
europepmc +1 more source