Results 91 to 100 of about 167,574,678 (311)

National Assessment of Vocational Education

open access: yes, 2005
The National Assessment of Vocational Education (NAVE) is a congressionally-mandated evaluation of the 1998 Carl D. Perkins Vocational and Technical Education Act and of the implementation and outcomes of vocational education in the United States.
National Assessment of Vocational Education
core  

Experimental and numerical investigations of the ball-screw-type coupling in two-dimensional electro-hydraulic proportional directional valve

open access: yesAdvances in Mechanical Engineering, 2018
To realize rotary and linear motions of a single spool for improving a proportional displacement of the spool, a new structure of ball screw compression–torsion coupling is proposed, which is used in the two-dimensional electro-hydraulic proportional ...
Qiang Zuo   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

A comparison of teaching qualifications in grades 10 through 12 mathematics [PDF]

open access: yes, 2022
Academic tracking is a standard practice for Grades 10-12 students in Alberta (Alberta Education, n.d.). Schools may also have locally developed enrichment or remedial mathematics programs.
University of Lethbridge. Faculty of Education   +1 more
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IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

From vision to reality, transforming PK-12 education in Ohio

open access: yes, 2008
Electronic coverage as of Dec. 23, 2009: 2006/2007-; Some reports also have a distinctive title.; Latest issue consulted: 2007/2008.; Description based on: 2006/2007; title from PDF cover (viewed on Dec. 23, 2009)
Ohio. State Board of Education.
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

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