Results 51 to 60 of about 167,574,678 (311)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Developing an understanding of the Kanadier Mennonite and implications for education [PDF]

, 2000
vii, 158 leaves ; 29 cm. --The project focuses on a unique migrant population in Horizon School Division called the Kanadier Mennonites. The Kanadier Mennonites who depart Mexico and other Latin American countries present a number of educational ...
Gilmore, Cheryl Anne, University of Lethbridge. Faculty of Education   +1 more
core  

Design and Characteristic Research on Variable Displacement Mechanism of Two-Dimensional (2D) Bivariable Pump

Energies
In a hydraulic system, a micro variable pump is required to be high pressure and high speed, and this work presents a new type of 2D bivariable pump structure in which the worm gear and worm mechanism are used to rotate the cylinder block to change the ...
Tong Xing, Xu Ji, Zeri Yang, Jian Ruan
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The impact of outdoor education on executive function in adolescents [PDF]

, 2020
This mixed-methods study investigated the nature of the impact of a multi-day outdoor education camp on the executive functions of sixth grade students (n = 29) in Alberta, Canada.
McKenzie, Jared Patrick, University of Lethbridge. Faculty of Education.   +1 more
core  

Estimation of the Time-Varying High-Intensity Heat Flux for a Two-Layer Hollow Cylinder

Energies, 2018
Gun barrels are subjected to time-varying high-intensity heat flux under multiple firing, which may damage the material and limit the overall performance of the gun.
Lihui Zhang, Zhenzhen Chen, Donghui Wen, Xudong Wang, Daqian Zhang, Jun Liang   +5 more
doaj   +1 more source

Effect of texture evolution on corrosion resistance of AZ80 magnesium alloy subjected to applied force in simulated body fluid

Materials Research Express, 2020
The electrochemical corrosion behavior of a rolled AZ80 magnesium alloy after pre-compressive strain along different orientation in a simulated body fluid (SBF) was investigated by immersion test for 48 h. The results showed that the corrosion resistance
Ying Xiong, Zengyuan Yang, Tao Zhu, Yanyao Jiang   +3 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source