Results 151 to 160 of about 167,732,555 (302)
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
What makes a successful student teacher in a teacher education program? [PDF]
, 2003 v, 68 leaves ; 29 cm. --The purpose of this project was to explore and investigate specific factors, qualities, and characteristics student teachers and teacher associates believe create teaching success in the classroom during a teacher education ...
Platt, Shari +1 more
core
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Other title: Fiscal Years 1986-88 State Plan for Vocational Education
, 1985 "Application for Federal Funds, P.L. 98-524." "Approved by Governor John Carlin, March 26, 1985." "Approved by State Board of Education, April 10, 1985.""The Fiscal Years 1986-88 State Plan for vocational education is an application for Federal funds ...
Kansas. State Department of Education.
core
The Purposes of Graduate Education: An Historical Perspective
Canadian Journal of Higher Education, 1973 M. A. Preston
doaj +1 more source
Ibérica, 2014 Given the varied roles Language for Specific Purposes (LSP) teachers typically play and the demanding nature of LSP teaching, the literature on teacher education for LSP is surprisingly limited. This paper examines the literature on LSP teacher education
Helen Basturkmen
doaj
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source