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Idiopathic Thrombocytopenic Purpura
Postgraduate Medicine, 1962The acute form of ITP may be drug-induced or may follow infection or exposure to chemicals. The chronic form represents a self-perpetuating immunologic (auto-immune) disorder, at times associated with chronic lymphatic leukemia and other disorders. In some cases, it may be a prodrome of systemic lupus, to which it seems to be closely related.
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Congenital thrombocytopenic purpura
The Journal of Pediatrics, 1947Summary Congenital thrombocytopenic purpura has occurred as a familial condition in three successive children of a mother previously splenectomized for thrombocytopenic purpura. In each of these children there has been a gradual spontaneous recovery to a normal blood picture during the first 2 months of life, and following recovery there has been no ...
Benjamin Berman, Janet Talmadge
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Immune Thrombocytopenic Purpura
Hematology/Oncology Clinics of North America, 2007Immune thrombocytopenic purpura (ITP) is an autoantibody-mediated thrombocytopenic disorder in which accelerated destruction of platelets occurs; platelet production may also be impaired by these antibodies. ITP is characterized by mucocutaneous bleeding. Rarely, more severe hemorrhages, such as intracranial hemorrhage, may occur. Traditional therapies,
James B. Bussel, Bethan Psaila
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An update on pathogenesis and diagnosis of thrombotic thrombocytopenic purpura
Expert Review of Hematology, 2019Introduction: Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, consumption thrombocytopenia, and organ injury. TTP pathophysiology is based on a severe
B. Joly, P. Coppo, A. Veyradier
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Idiopathic Thrombocytopenic Purpura
New England Journal of Medicine, 1966A CHANGE in the concepts regarding idiopathic thrombocytopenic purpura has occurred during the past fifteen years mainly because of the recognition of three important facts: The thrombocytopenia is the result of increased platelet destruction. The old hypothesis, originally postulated by Frank,1 , 2 of a toxic depression of megakaryocytes and their ...
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Thrombotic thrombocytopenic purpura
Journal of Thrombosis and Haemostasis, 2005This overview summarizes the history of thrombotic thrombocytopenic purpura (TTP) from its initial recognition in 1924 as a most often fatal disease to the discovery in 1997 of ADAMTS-13 deficiency as a major risk factor for acute disease manifestation.
J. A. Kremer Hovinga +2 more
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Idiopathic Thrombocytopenic Purpura
Pediatrics In Review, 20001. Yu-Waye Chu, MD* 2. James Korb, MD† 3. Kathleen M. Sakamoto, MD* 1. 2. *Division of Hematology-Oncology, Department of Pediatrics. 3. 4. †Division of General Pediatrics, Department of Pediatrics, UCLA School of Medicine, Los Angeles, CA.
James Korb +2 more
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Thrombotic Thrombocytopenic Purpura
Annual Review of Medicine, 1988Platelet thrombus formation in small vessels is triggered by certain stimuli, including vascular injury, primary platelet agglutination, or both. The formation and dissolution of platelet thrombi is modulated by proteolysis, plasma factors, PGI2 synthesis and stability, and immune mechanisms.
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Immune Thrombocytopenic Purpura
JCR: Journal of Clinical Rheumatology, 1997Thrombocytopenia is seen commonly in patients with rheumatic disorders. In general, thrombocytopenia is due to one of three mechanisms: reduced production, sequestration, or increased platelet destruction. In outpatients, the most common cause of thrombocytopenia is immune thrombocytopenia. Immune thrombocytopenia encompasses a broad group of disorders
Mark Crowther, John G. Kelton
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Thrombotic thrombocytopenic purpura
Disease-a-Month, 2014Moschowitz first described thrombotic thrombocytopenic purpura (TTP) in 1925 in a 16-yearold female who presented with fever, petechiae, and a microangiopathic hemolytic anemia. Autopsy examination at the time revealed hyaline thrombi in the vascular beds of many organs. By 1947, several more cases were described and Singer suggested the term TTP.
Rami Y. Haddad +3 more
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