Results 91 to 100 of about 46,143 (249)

Presumptive thrombotic thrombocytopenic purpura following a hump-nosed viper (Hypnale hypnale) bite: a case report

Journal of Venomous Animals and Toxins including Tropical Diseases, 2014
Hump-nosed viper bites are frequent in southern India and Sri Lanka. However, the published literature on this snakebite is limited and its venom composition is not well characterized.
Milinda Withana, Chaturaka Rodrigo, Ariaranee Gnanathasan, Lallindra Gooneratne   +3 more
doaj   +1 more source

Open or closed? Understanding the molecular mechanisms and clinical implications of ADAMTS13's conformation

HemaSphere, Volume 9, Issue 7, July 2025.
Abstract By proteolyzing prothrombotic von Willebrand factor (VWF) multimers, ADAMTS13 (A Disintegrin And Metalloproteinase with ThromboSpondin type‐1 repeats, member 13) ensures balanced hemostasis and prevents microvascular thrombosis. ADAMTS13's conformational regulation is not only crucial for its enzymatic function, but also for the ...
Quintijn Bonnez, Karen Vanhoorelbeke
wiley   +1 more source

Thrombotic thrombocytopenic purpura: Toward targeted therapy and precision medicine

Research and Practice in Thrombosis and Haemostasis, 2018
Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy characterized by severe congenital or immune‐mediated deficiency in ADAMTS13, the enzyme that cleaves von Willebrand factor multimers.
P. Coppo, A. Cuker, J. George
semanticscholar   +1 more source

Acute Hepatitis E Induced the First Episode of Immune-Mediated Thrombotic Thrombocytopenic Purpura: The First Case Report

Infection and Drug Resistance, 2023
Fei Lv,1,2 Yue Zhao,2 Xing-Di Yang,2 Han-Zhu Chen,2 Wen-Ya Ren,2 Ling-Xia Chen,2 Qiao-Qiao Yi,2 Wei Zheng,2 Hong-Ying Pan2 1The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, People’s Republic of China ...
Lv F, Zhao Y, Yang XD, Chen HZ, Ren WY, Chen LX, Yi QQ, Zheng W, Pan HY   +8 more
doaj  

What Are Appropriate Initial and Salvage Therapies for Patients with Thrombotic Thrombocyopenic Purpura (TTP)?

Acta Medica, 2004
Although much has been learned about the pathophysiologic process of thrombotic thrombocytopenic purpura (TTP), both diagnostically and therapeutically, since its initial description by Moschowitz in 1924, its etiology and treatments remain, in many ...
Leo McCarthy, Atillio Orazi, Charles Miraglia, Daniel Waxman, Elaine Skipworth, Constance Danielson   +5 more
doaj   +1 more source

FIGO guideline on liver disease and pregnancy

International Journal of Gynecology &Obstetrics, Volume 170, Issue 1, Page 28-48, July 2025.
Abstract The number of women entering pregnancy with chronic liver disease is rising. Gestational liver disorders affect 3% of the pregnant population. Both can be associated with significant maternal and fetal morbidity and mortality. European guidance has recently been published to inform management.
Melanie Nana, Virna Medina, Cynthia Maxwell, Ciara McCormick, Gloria Taliani, Ulrich Beuers, Deborah Money, Bo Jacobsson, Anil Kapur, Titus Beyuo, Francisco Ruiloba, Graeme Smith, Lina Bergman, Sharleen O'Reilly, Patrick O'Brien, Mark Hanson, Mary Rosser, Claudio Sosa, Sumaiya Adam, Valerie Guinto, Liona Poon, Fionnuala McAuliffe, Catherine Williamson, on behalf of the FIGO Committee on Impact of Pregnancy on Long‐term Health, FIGO Committee on Infections during Pregnancy and the FIGO Division of Maternal and Newborn Health   +24 more
wiley   +1 more source

Thrombotic Thrombocytopenic Purpura and Gemcitabine [PDF]

Case Reports in Oncology, 2011
Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening complication of gemcitabine treatment. Since the approval of this nucleoside analog for the treatment of pancreatic cancer by the FDA in 1996, reported incidence varies from 0.015 to 1.4%.
openaire   +4 more sources

Diagnosis of thrombotic thrombocytopenic purpura

Terapevticheskii arkhiv, 2020
Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening disease, disease, characterised by microangiopathic hemolytic anaemia, consumption thrombocytopenia, and organ dysfunction. The pathogenesis of TTP is attributed to the deficiency in the activity of the metalloproteinase ADAMTS13, specific von Willebrand factor cleaving protease. TTP
G. M. Galstyan, E. E. Klebanova
openaire   +4 more sources

Intracranial Hemorrhage Due to Secondary Hypertension from Intracranial Large Vessel Occlusion [PDF]

, 2020
Simultaneous hemorrhagic and ischemic strokes have been previously reported in the literature. Typically, these occur in patients secondary to dialysis, cerebral amyloid angiopathy, or thrombotic thrombocytopenic purpura.1,2,3 However, this is the unique
Khan, Asif A., Rawal, Amit, Saeed, Omar, Waldman, Alex   +3 more
core  

Rituximab induced pulmonary edema managed with extracorporeal life support [PDF]

, 2018
Though rare, rituximab has been reported to induce severe pulmonary edema. We describe the first report of ECLS utilization for this indication. A 31-year-old female with severe thrombotic thrombocytopenic purpura developed florid pulmonary edema after ...
Aguilar, Patrick, Balsara, Keki R, Isakow, Warren, Itoh, Akinobu, Masood, Muhammad F, Miller, Jacob R, Sanfilippo, Kristen M   +6 more
core   +3 more sources