Results 101 to 110 of about 46,143 (249)

Progress in Aptamer Research and Future Applications

ChemistryOpen, Volume 14, Issue 7, July 2025.
This paper mainly describes the screening method of aptamer, the screening difficulties and improvement methods of small molecule aptamer, and the application and treatment of aptamer. It explores the latest progress and application of aptamers, and summarises them, thus indicating some problems that still exist in this field.
Song Liu, Xiaolu Li, Huyang Gao, Jing Chen, Hongfeng Jiang   +4 more
wiley   +1 more source

Target‐Mediated Drug Disposition (TMDD) Revisited: High Versus Low‐Affinity Approximations of the TMDD Model

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 7, Page 1262-1272, July 2025.
ABSTRACT Target‐mediated drug disposition (TMDD) is often associated with high‐affinity binding to a target resulting in nonlinear pharmacokinetics. For large molecules, such as monoclonal antibodies, this can lead to increased clearance at sub‐saturating concentrations.
Ronny Straube
wiley   +1 more source

Complete Recovery of Ischemic Cardiomyopathy from Thrombotic Thrombocytopenic purpura

Clinical Medicine Insights: Cardiology, 2011
A 50 year old male HIV patient on antiretroviral therapy was admitted for chest pain. Upon admission, the patient was found to have elevated cardiac enzymes, acute thrombocytopenia, hemolytic anemia, acute pancreatitis and acute renal failure.
Sainath Gaddam, Lata Pablani, Vinod Chainani, Ravi Raj Kavuda, Tarun Nagrani, Georges Abou Rjaili, Meekoo Dhar, James C Lafferty   +7 more
doaj   +1 more source

Severe Acral Necrosis Complicating Thrombotic Microangiopathy in Two Toddlers

Case Reports in Pediatrics, 2020
Acral ischemia/necrosis is one of the rarest but most dreadful complications of thrombotic microangiopathy in pediatric patients. It is more reported with thrombotic thrombocytopenic purpura than with hemolytic and uremic syndrome.
H. Nassih, Z. Lazrak, S. Younous
doaj   +1 more source

Ventilation/perfusion SPECT in children: Feasibility, impact on clinical decision‐making and interrater agreement

Clinical Physiology and Functional Imaging, Volume 45, Issue 4, July 2025.
Abstract Introduction It remains to be established whether it provides any clinical or diagnostic benefits to perform ventilation/perfusion (V/Q) scintigraphy as a single photon emission computed tomography in children. Here, we report our experience with this modality, evaluate its impact on clinical decision‐making and assess its interrater agreement.
Lise Borgwardt, Mette Louise Mørk, Henrik Gutte, Anne Kiil Berthelsen, Robin de Nijs, Ronan M. G. Berg, Jann Mortensen   +6 more
wiley   +1 more source

ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis [PDF]

, 2005
Members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family are known to influence development, angiogenesis, coagulation and progression of arthritis.
Jones, GC, Riley, GP
core   +2 more sources

Integrating Next‐Generation Sequencing Into Routine Molecular Diagnosis of Inherited Coagulation Factor Deficiencies: Real‐World Data From Spanish Patients

Haemophilia, Volume 31, Issue 4, Page 734-742, July 2025.
ABSTRACT Introduction Inherited coagulation factor deficiencies (ICFD) result from plasma protein deficiencies, impacting blood coagulation cascade and leading to haemorrhagic diathesis. Advancements in next‐generation sequencing (NGS) technology have enabled high‐throughput methods for molecular ICFD diagnosis.
Nina Borràs, Natàlia Comes, Lorena Ramírez, Rafael Parra, Carmen Altisent, Álvaro Lorenzo‐Vizcaya, Cristina Marzo‐Alonso, Maria‐Fernanda López‐Fernández, Mariana Canaro, María Falcón‐Rodríguez, Ángela Cortes‐Vidal, Mario A. Rios de Paz, José Antonio Rodríguez‐García, Ana Moreto‐Quintana, Perla Bandini, Carlos Hobeich, Irene Corrales, Francisco Vidal   +17 more
wiley   +1 more source

Thrombotic Thrombocytopenic Purpura [PDF]

BMJ, 1954
In 1924 Moschcowitz reported the case of a patient who died following a brief illness characterized by fever, haernolytic anaemia, a bleeding tendency, and terminal neurological signs. Histological examination revealed widespread hyaline thromboses in the capillaries and terminal arterioles, Baehr et al.
O. C. Lloyd, D. J. Ellison
openaire   +2 more sources

Frequency and Significance of HIV Infection among Patients Diagnosed with Thrombotic Thrombocytopenic Purpura [PDF]

, 2017
Background. Case series of patients with a diagnosis of thrombotic thrombocytopenic purpura (TTP) have reported different frequencies of human immunodeficiency virus (HIV) infection; some series suggest that HIV infection may cause TTP. Methods.
Benjamin, Melody, Dezube, Bruce J., George, James N., Kremer Hovinga, Johanna A., Lämmle, Bernhard, Terrell, Deirdra R., Vesely, Sara K., Voskuhl, Gene W.   +7 more
core  

Elevated plasma neutrophil elastase concentration is associated with disease activity in patients with thrombotic thrombocytopenic purpura. [PDF]

, 2015
INTRODUCTION: Genetic and autoimmune risk factors contribute to the development of thrombotic thrombocytopenic purpura (TTP) but triggers are needed to bring about acute disease.
Brill, Brinkmann, Brinkmann, Bálint Mikes, Chapman, Chaturvedi, Chen, Clark, Clark, Derzsy, Dorottya Csuka, Falter, Fitzpatrick, Fuchs, Fujimura, Gombos, Gyula Domján, György Sinkovits, Hung, Ishikawa, Jagels, Judit Demeter, Karpman, Katalin Rázsó, Kessenbrock, Kremer Hovinga, Leffler, Marienn Réti, Massberg, Moatti-Cohen, Noris, Papayannopoulos, Peng, Peyvandi, Péter Farkas, Raife, Reti, Tsai, Urban, van Montfoort, Walters, Westwood1, Xu, Zoltán Prohászka, Ágota Schlammadinger   +44 more
core   +1 more source