Results 181 to 190 of about 22,264 (222)

Autoimmunity in Thrombotic Thrombocytopenic Purpura

Seminars in Thrombosis and Hemostasis, 2005
In the last few years, an autoimmune hypothesis for the pathogenesis of thrombotic thrombocytopenic purpura (TTP) has been proposed often, with variable success because of inconsistent supporting data. We are now aware that at least one subgroup of TTP patients does present with pathogenic autoantibodies (i.e, anti-ADAMTS13); this group consequently is
Porta, Camillo, CAPORALI, ROBERTO, MONTECUCCO, CARLOMAURIZIO   +2 more
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Thrombotic thrombocytopenic purpura in pregnancy

BJOG: An International Journal of Obstetrics & Gynaecology, 1982
Summary. A 20 week primigravida with intrauterine fetal death and the rare occurrence of thrombotic thrombocytopenic purpura (TTP) in pregnancy is presented. Aprotinin has been used to overcome uterine inertia non‐responsive to oxytocin stimulation. TTP was successfully treated with repeated plasmaphereses.
M, Atlas, G, Barkai, J, Menczer, N, Houlu, P, Lieberman   +4 more
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Thrombotic thrombocytopenic purpura in childhood

Pediatric Blood & Cancer, 2009
AbstractThrombotic thrombocytopenic purpura (TTP) is a rare disease, especially in childhood, and has a high mortality rate in the absence of appropriate treatment. It is characterised by microangiopathic haemolytic anaemia and consumptive thrombocytopenia.
Maria C, Bouw, Natasja, Dors, Heleen, van Ommen, Nicole L, Ramakers-van Woerden   +3 more
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Thrombotic Thrombocytopenic Purpura

Annual Review of Medicine, 1988
Platelet thrombus formation in small vessels is triggered by certain stimuli, including vascular injury, primary platelet agglutination, or both. The formation and dissolution of platelet thrombi is modulated by proteolysis, plasma factors, PGI2 synthesis and stability, and immune mechanisms.
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Thrombotic Thrombocytopenic Purpura

Annals of Internal Medicine, 1980
Excerpt Originally described in 1925 (1), thrombotic thrombocytopenic purpura remained until recently a fulminating and rapidly fatal disorder. Fortunately, it has been rare.
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Thrombotic Thrombocytopenic Purpura and Vincristine

JAMA: The Journal of the American Medical Association, 1982
To the Editor.— We were interested in the recent article inThe Journal(1982;247:1433) by Lorence A. Gutterman, MD, and Thomas D. Stevenson, MD, which demonstrates that vincristine sulfate is capable of inducing remissions in patients with thrombotic thrombocytopenic purpura (TTP).
W J, Gundlach, R, Tarnasky
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Thrombotic Thrombocytopenic Purpura

JAMA: The Journal of the American Medical Association, 1982
Though thrombotic thrombocytopenic purpura (TTP) is not a common disorder, having an estimated annual incidence of one per million population, it merits attention.1First, it afflicts those in the prime of life between the third and fourth decade. Second, it generally runs a fulminant course with mortality in excess of 8096.
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Complement in thrombotic thrombocytopenic purpura

American Journal of Hematology, 1983
AbstractThis report describes a patient with recurrent thrombotic thrombocytopenic purpura (TTP)in whom complement activation was observed during the acute episodes. Serum C3, C4, and CH50 were reduced, and there was deposition of C3 on red cells and platelets. These findings returned to normal during clinical remission.
M B, Garvey, J, Freedman
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Thrombotic thrombocytopenic purpura in siblings

The American Journal of Medicine, 1967
Abstract Reported herein are two cases of thrombotic thrombocytopenic purpura in sisters. In both the disease ran a chronic course terminating in the final episode of thrombotic thrombocytopenic purpura. Many of the clinical and pathologic findings resembled those in systemic lupus erythematosus.
S A, Norkin, H H, Freedman, G W, Evans
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Thrombotic Thrombocytopenic Purpura-Then and Now

Seminars in Thrombosis and Hemostasis, 2006
Thrombotic thrombocytopenic purpura (TTP) is a potentially life-threatening disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, and formation of microthrombi in several organs. The disease may manifest once in a lifetime or may relapse after complete recovery of the initial episode; in these recurrent cases, death or ...
Miriam, Galbusera, Marina, Noris, Giuseppe, Remuzzi   +2 more
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