Results 41 to 50 of about 46,143 (249)

Platelet Apoptosis in Adult Immune Thrombocytopenia: Insights into the Mechanism of Damage Triggered by Auto-antibodies [PDF]

, 2016
Mechanisms leading to decreased platelet count in immune thrombocytopenia (ITP) are heterogeneous. This study describes increased platelet apoptosis involving loss of mitochondrial membrane potential (ΔΨm), caspase 3 activation (aCasp3) and ...
Contrufo, Geraldine, Espasandin, Yesica Romina, García, Alejandro Jorge, Glembotsky, Ana Claudia, Goette, Nora Paula, Grodzielski, Matías, Heller, Paula Graciela, Lev, Paola Roxana, Marta, Rosana Fernanda, Molinas, Felisa Concepción, Pierdominici, Marta S., Riveros, Dardo Alberto   +11 more
core   +1 more source

Acquired thrombotic thrombocytopenic purpura: A rare disease associated with BNT162b2 vaccine

Journal of Thrombosis and Haemostasis, 2021
In December 2020 the Israeli Health Ministry began a mass vaccination campaign with the BNT162b2 vaccine. This was an important step in overcoming the severe acute respiratory syndrome corona virus 2 (SARS‐CoV‐2) pandemic. Autoimmune phenomenon have been
H. Maayan, I. Kirgner, O. Gutwein, K. Herzog-Tzarfati, N. Rahimi-Levene, M. Koren-Michowitz, D. Blickstein   +6 more
semanticscholar   +1 more source

Prognostic factors in thrombotic thrombocytopenic purpura

Türk Biyokimya Dergisi, 2022
Thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy with no standardized prognostic model to predict mortality. The aim of the study is to determine parameters associated with TTP-related mortality.
Yalçıner Merih, İlhan Osman
doaj   +1 more source

A case of refractory thrombotic thrombocytopenic purpura treated with plasmapheresis and rituximab [PDF]

, 2016
Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening disorder with no prevalence or incidence studies in sub-Saharan Africa. Acquired TTP has several causes, all of which lead to decreased activity of von Willebrand factor cleaving ...
Kirui, Nicholas, Sokwala, Ahmed
core   +4 more sources

Sequential occurrence of thrombotic thrombocytopenic purpura, essential thrombocythemia, and idiopathic thrombocytopenic purpura in a 42-year-old African-American woman: a case report and review of the literature

Journal of Medical Case Reports, 2012
Introduction Thrombotic thrombocytopenic purpura and idiopathic thrombocytopenic purpura are two well recognized syndromes that are characterized by low platelet counts. In contrast, essential thrombocythemia is a myeloproliferative disease characterized
Farhat Mirna H, Kuriakose Philip, Jawad Michael, Hanbali Amr   +3 more
doaj   +1 more source

Degradation of two novel congenital TTP ADAMTS13 mutants by the cell proteasome prevents ADAMTS13 secretion [PDF]

, 2016
INTRODUCTION: Over 150 mutations have been identified in the ADAMTS13 gene in patients with congenital thrombotic thrombocytopenic purpura (TTP). The majority of these (86%), lead to reduced (
Garagiola, I, Machin, S, Mackie, I, Peyvandi, F, Underwood, M   +4 more
core   +1 more source

Campylobacter Jejuni and Thrombotic Thrombocytopenic Purpura

Canadian Journal of Gastroenterology, 1990
Gastrointestinal bacterial infections could be associated with multisystem complication due to the thrombotic phenomena. This paper reports the association of Campylobacter jejuni infection and thrombotic thrombocytopenic purpura, and describes a new ...
Roman Jaeschke, E Jan Irvine, Jane Moore, John Kelton   +3 more
doaj   +1 more source

Long-term Kidney Outcomes in Patients With Acquired Thrombotic Thrombocytopenic Purpura

Kidney International Reports, 2017
Severe acute kidney injury (AKI) and chronic kidney disease (CKD) are considered to be uncommon in patients with acquired thrombotic thrombocytopenic purpura.
Dustin J. Little, Lauren M. Mathias, Evaren E. Page, Johanna A. Kremer Hovinga, Sara K. Vesely, James N. George   +5 more
doaj   +1 more source

Thrombotic microangiopathies: thrombotic thrombocytopenic purpura / hemolytic uremic syndrome [PDF]

, 2010
Thrombotic microangiopathies (TMAs) are pathological conditions characterized by generalized microvascular occlusion by platelet thrombi, thrombocytopenia, and microangiopathic hemolytic anemia.
Mastroianni Kirsztajn, Gianna, Polito, Maria Goretti   +1 more
core   +2 more sources

Treatment of acquired thrombotic thrombocytopenic purpura without plasma exchange in selected patients under caplacizumab

Journal of Thrombosis and Haemostasis, 2020
Acquired thrombotic thrombocytopenic purpura (aTTP) is a rare, life‐threatening autoimmune thrombotic microangiopathy. Current standard of care is therapeutic plasma exchange, immunosuppression, and caplacizumab, an anti‐von Willebrand factor nanobody ...
L. Völker, P. Brinkkoetter, P. Knöbl, M. Krstić, J. Kaufeld, J. Menne, V. Buxhofer-Ausch, W. Miesbach   +7 more
semanticscholar   +1 more source