Results 71 to 80 of about 36,176 (202)

Sunitinib Induced Thrombotic Thrombocytopenic Purpura in addition to Severe Hypothyroidism: A Case Report and Review of the Literature

Case Reports in Medicine, 2014
Introduction. Sunitinib malate is an oral multitargeting tyrosine kinase inhibitor approved for the first line treatment of metastatic renal cell carcinoma.
Imane El Dika, Deborah Mukherji, Sally Temraz, Rita Assi, Ali Shamseddine   +4 more
doaj   +1 more source

Thrombotic Thrombocytopenic Purpura and Gemcitabine [PDF]

Case Reports in Oncology, 2011
Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening complication of gemcitabine treatment. Since the approval of this nucleoside analog for the treatment of pancreatic cancer by the FDA in 1996, reported incidence varies from 0.015 to 1.4%.
openaire   +4 more sources

Preemptive rituximab prevents long-term relapses in immune-mediated thrombotic thrombocytopenic purpura.

Blood, 2018
Preemptive rituximab infusions prevent relapses in immune thrombotic thrombocytopenic purpura (iTTP) by maintaining normal ADAMTS13 activity. However, the long-term outcome of these patients and the potential adverse events of this strategy need to be ...
M. Jestin, Y. Benhamou, A. Schelpe, E. Roose, F. Provôt, L. Galicier, M. Hié, C. Presne, P. Poullin, A. Wynckel, S. Saheb, C. Deligny, A. Servais, S. Girault, Yahsou Delmas, T. Kanouni, A. Lautrette, D. Chauveau, C. Mousson, P. Pérez, J. Halimi, A. Charvet-Rumpler, M. Hamidou, P. Cathébras, K. Vanhoorelbeke, A. Veyradier, P. Coppo   +26 more
semanticscholar   +1 more source

Causal relationship between immune cells and idiopathic thrombocytopenic purpura: A bidirectional Mendelian randomization study

Rheumatology &Autoimmunity, EarlyView.
Heyi Zhang, Luyao Song, Ying Mao, Zerui Liu, Zhexi He, Mengxia Liu, Jingfang Zhang, Rui Zhao, Jing Luo, Shengxiao Zhang   +9 more
wiley   +1 more source

Presumptive thrombotic thrombocytopenic purpura following a hump-nosed viper (Hypnale hypnale) bite: a case report

Journal of Venomous Animals and Toxins including Tropical Diseases, 2014
Hump-nosed viper bites are frequent in southern India and Sri Lanka. However, the published literature on this snakebite is limited and its venom composition is not well characterized.
Milinda Withana, Chaturaka Rodrigo, Ariaranee Gnanathasan, Lallindra Gooneratne   +3 more
doaj   +1 more source

Diagnosis of thrombotic thrombocytopenic purpura

Terapevticheskii arkhiv, 2020
Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening disease, disease, characterised by microangiopathic hemolytic anaemia, consumption thrombocytopenia, and organ dysfunction. The pathogenesis of TTP is attributed to the deficiency in the activity of the metalloproteinase ADAMTS13, specific von Willebrand factor cleaving protease. TTP
G. M. Galstyan, E. E. Klebanova
openaire   +4 more sources

Quantitative Systems Pharmacology Modeling of Platelet Responses to Recombinant ADAMTS13 in Patients With Congenital Thrombotic Thrombocytopenic Purpura

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 10, Page 1575-1586, October 2025.
ABSTRACT Congenital thrombotic thrombocytopenic purpura (cTTP) is an ultra‐rare, life‐threatening thrombotic microangiopathy caused by a severe inherited deficiency of ADAMTS13, a von Willebrand factor (VWF) cleaving enzyme. Inadequate clinical endpoint data often make it challenging to statistically power clinical trials in ultra‐rare diseases ...
Cameron McBride, Jiaolong Jiang, Zhiwei Zhang, John Tolsma, Parth Patwari, Björn Mellgård, Majid Vakilynejad, Indranil Bhattacharya, Andy Z. X. Zhu   +8 more
wiley   +1 more source

Acute Hepatitis E Induced the First Episode of Immune-Mediated Thrombotic Thrombocytopenic Purpura: The First Case Report

Infection and Drug Resistance, 2023
Fei Lv,1,2 Yue Zhao,2 Xing-Di Yang,2 Han-Zhu Chen,2 Wen-Ya Ren,2 Ling-Xia Chen,2 Qiao-Qiao Yi,2 Wei Zheng,2 Hong-Ying Pan2 1The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, People’s Republic of China ...
Lv F, Zhao Y, Yang XD, Chen HZ, Ren WY, Chen LX, Yi QQ, Zheng W, Pan HY   +8 more
doaj  

Thrombotic thrombocytopenic purpura: Toward targeted therapy and precision medicine

Research and Practice in Thrombosis and Haemostasis, 2018
Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy characterized by severe congenital or immune‐mediated deficiency in ADAMTS13, the enzyme that cleaves von Willebrand factor multimers.
P. Coppo, A. Cuker, J. George
semanticscholar   +1 more source

Diffuse Alveolar Haemorrhage Complicated by Pulmonary Metastasis of Cardiac Angiosarcoma and Kasabach–Merritt Syndrome: A Case Report

Respirology Case Reports, Volume 13, Issue 10, October 2025.
We report an exceptional case of cardiac angiosarcoma in which diffuse alveolar haemorrhage was caused by both pulmonary metastases and Kasabach–Merritt syndrome. Strategies to achieve transfusion‐independent haemostasis such as high PEEP may create an opportunity for prompt biopsy and facilitate timely initiation of definitive treatment.
Takuma Ikeda, Satoru Terada, Kazuo Endo
wiley   +1 more source