Results 81 to 90 of about 36,176 (202)

What Are Appropriate Initial and Salvage Therapies for Patients with Thrombotic Thrombocyopenic Purpura (TTP)?

Acta Medica, 2004
Although much has been learned about the pathophysiologic process of thrombotic thrombocytopenic purpura (TTP), both diagnostically and therapeutically, since its initial description by Moschowitz in 1924, its etiology and treatments remain, in many ...
Leo McCarthy, Atillio Orazi, Charles Miraglia, Daniel Waxman, Elaine Skipworth, Constance Danielson   +5 more
doaj   +1 more source

Co‐Occurrence of HIV‐Susceptibility and ‐Protective HLA Alleles Is a Possible Contributor to the Development of Primary HIV‐Associated Thrombocytopenia (PHAT): A Cross‐Sectional Study

International Journal of Immunogenetics, Volume 52, Issue 5, Page 249-255, October 2025.
ABSTRACT Primary HIV‐associated thrombocytopenia (PHAT) is an isolated thrombocytopenia in HIV‐positive individuals in the absence of secondary causes. The presence of certain Human Leukocyte Antigens (HLA) has been linked to individuals’ immune response to HIV and the development of immune‐mediated thrombocytopenic disorders.
Walter J Janse van Rensburg, Anne‐Cecilia van Marle, Lomari Geertsema   +2 more
wiley   +1 more source

Thrombotic thrombocytopenic purpura: Description and analysis of 23 cases treated in Chile between 2017 and 2022

Medwave
Introduction Since the first description of Thrombotic Thrombocytopenic Purpura, caused by a severe deficiency of ADAMTS13, plasma exchange and immunosuppression have become standard treatments, allowing to decrease its high mortality rate.
Daniel Cathalifaud, Jean-Paul Manríquez, Benjamín Rodríguez, Gonzalo Eymin, Benjamín Sanfuentes, Joel Castellano, Andrés Valenzuela   +6 more
doaj   +1 more source

Rare onset of congenital thrombotic thrombocytopenic purpura during pregnancy: A novel ADAMTS13 gene variant

Transfusion, Volume 65, Issue 10, Page 1982-1988, October 2025.
Abstract Background Congenital thrombotic thrombocytopenic purpura (cTTP) is a rare autosomal recessive thrombotic microangiopathy caused by biallelic mutations in ADAMTS13, leading to severe enzyme deficiency. The absence of ADAMTS13 prevents cleavage of ultra‐large von Willebrand factor multimers, resulting in platelet‐rich microthrombi formation ...
Rita González‐Resina, Mar Herrero‐Gutiérrez, Inés Gómez‐Seguí, Jorge Martínez‐Nieto, Ángeles Montañés, Ana Belén Roche Latasa, Valle Recasens   +6 more
wiley   +1 more source

Complete Recovery of Ischemic Cardiomyopathy from Thrombotic Thrombocytopenic purpura

Clinical Medicine Insights: Cardiology, 2011
A 50 year old male HIV patient on antiretroviral therapy was admitted for chest pain. Upon admission, the patient was found to have elevated cardiac enzymes, acute thrombocytopenia, hemolytic anemia, acute pancreatitis and acute renal failure.
Sainath Gaddam, Lata Pablani, Vinod Chainani, Ravi Raj Kavuda, Tarun Nagrani, Georges Abou Rjaili, Meekoo Dhar, James C Lafferty   +7 more
doaj   +1 more source

Thrombotic Thrombocytopenic Purpura [PDF]

BMJ, 1954
In 1924 Moschcowitz reported the case of a patient who died following a brief illness characterized by fever, haernolytic anaemia, a bleeding tendency, and terminal neurological signs. Histological examination revealed widespread hyaline thromboses in the capillaries and terminal arterioles, Baehr et al.
O. C. Lloyd, D. J. Ellison
openaire   +2 more sources

Plasma transfusion practice: A five‐year audit of plasma transfusion at 23 hospitals

Transfusion, Volume 65, Issue 10, Page 1839-1850, October 2025.
Abstract Background There is limited high‐quality evidence to guide plasma transfusion, and plasma transfusion practices remain variable. Study design and methods This is a retrospective cohort study that included adult medical and intensive care unit (ICU) inpatients (age ≥ 18 years) admitted to 23 hospitals in Canada between January 1, 2017, and ...
Nadia Gabarin, Phuong Uyen Nguyen, Na Li, Anne Loeffler, Sheharyar Raza, Nicole Relke, Sarah Ryan, Justyna Bartoszko, Yang Liu, Malcolm Risk, Fahad Razak, Amol Verma, Donald M. Arnold, Jeannie Callum   +13 more
wiley   +1 more source

Severe Acral Necrosis Complicating Thrombotic Microangiopathy in Two Toddlers

Case Reports in Pediatrics, 2020
Acral ischemia/necrosis is one of the rarest but most dreadful complications of thrombotic microangiopathy in pediatric patients. It is more reported with thrombotic thrombocytopenic purpura than with hemolytic and uremic syndrome.
H. Nassih, Z. Lazrak, S. Younous
doaj   +1 more source

Autoimmune thrombotic thrombocytopenic purpura (TTP) associated with COVID-19

Annals of Hematology, 2020
Dear Editor: A 57-year-old woman with a history of hypertension and breast cancer in complete remission was seen in lateMarch 2020 at the emergency ward in a private clinic with dry cough, anosmia, and dysgeusia.
N. Albiol, R. Awol, R. Martino
semanticscholar   +1 more source

Idiopathic combined, autoantibody-mediated ADAMTS-13/factor H deficiency in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome in a 17-year-old woman: a case report

Journal of Medical Case Reports, 2011
Introduction Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome is a life-threatening condition with various etiopathogeneses. Without therapy approximately 90% of all patients die from the disease. Case presentation We report the case of a 17-
Patschan Daniel, Korsten Peter, Behlau Arne, Vasko Radovan, Heeg Malte, Sweiss Nadera, Müller Gerhard A, Koziolek Michael   +7 more
doaj   +1 more source