Acute cerebellar knockdown of Sgce reproduces salient features of myoclonus-dystonia (DYT11) in mice
eLife, 2019 Myoclonus dystonia (DYT11) is a movement disorder caused by loss-of-function mutations in SGCE and characterized by involuntary jerking and dystonia that frequently improve after drinking alcohol.
Samantha Washburn +4 more
doaj +1 more source
“Ghost tablet” husks excreted in feces in large bupropion XL overdose [PDF]
, 2018 Background: Extended-release medications are widely prescribed across the spectrum of medical specialties; however, there is heterogeneity in how they are formulated.
Nanagas, Kristine +2 more
core +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Alteration of transcriptomic networks in adoptive-transfer experimental autoimmune encephalomyelitis
Frontiers in Integrative Neuroscience, 2007 Adoptive transfer experimental autoimmune encephalomyelitis (AT-EAE) is an inflammatory demyelination that recapitulates in mouse spinal cord (SC) the human multiple sclerosis disease.
Dumitru A Iacobas +4 more
doaj +1 more source
Spatial contextual effects in primary visual cortex limit feature representation under crowding
Nature Communications, 2020 Visual crowding can strongly limit perceptual discriminability, yet its neural basis remains unclear. Here, the authors show that perceptual crowding is similar in monkeys and humans, and that feature encoding in neuronal populations in primary visual ...
Christopher A. Henry, Adam Kohn
doaj +1 more source
How I treat thrombotic thrombocytopenic purpura and atypical haemolytic uraemic syndrome [PDF]
, 2014 Thrombotic thrombocytopenic purpura (TTP) and atypical haemolytic uraemic syndrome (aHUS) are acute, rare life-threatening thrombotic microangiopathies that require rapid diagnosis and treatment.
Goodship, T, Scully, M
core +1 more source
STAR Protocols, 2023 Summary: Presynaptic boutons in the mammalian brain are typically small and difficult to manipulate and study. Here, we present a protocol applying HaloTag self-labeling technology to detect de novo local protein synthesis in intact presynaptic mossy ...
Shivani C. Kharod +3 more
doaj +1 more source
Pauci-immune glomerulonephritis in individuals with disease associated with levamisole-adulterated cocaine: a series of 4 cases. [PDF]
, 2014 Exposure to levamisole-adulterated cocaine can induce a distinct clinical syndrome characterized by retiform purpura and/or agranulocytosis accompanied by an unusual constellation of serologic abnormalities including antiphospholipid antibodies, lupus ...
Butcher, Brad +6 more
core +2 more sources
Coordination between Translation and Degradation Regulates Inducibility of mGluR-LTD
Cell Reports, 2015 Dendritic protein homeostasis is crucial for most forms of long-term synaptic plasticity, and its dysregulation is linked to a wide range of brain disorders.
Matthew E. Klein +2 more
doaj +1 more source
A role for cerebellum in the hereditary dystonia DYT1
eLife, 2017 DYT1 is a debilitating movement disorder caused by loss-of-function mutations in torsinA. How these mutations cause dystonia remains unknown. Mouse models which have embryonically targeted torsinA have failed to recapitulate the dystonia seen in patients,
Rachel Fremont +3 more
doaj +1 more source