Results 21 to 30 of about 56,696 (118)

Tapering thrombopoietin receptor agonists in primary immune thrombocytopenia: Expert consensus based on the RAND/UCLA modified Delphi panel method

Research and Practice in Thrombosis and Haemostasis, 2021
Background Thrombopoietin receptor agonists (TPO‐RAs) are used to treat primary immune thrombocytopenia (ITP). Some patients have discontinued treatment while maintaining a hemostatic platelet count.
Adam Cuker, Jenny M. Despotovic, Rachael F. Grace, Caroline Kruse, Michele P. Lambert, Howard A. Liebman, Roger M. Lyons, Keith R. McCrae, Vinod Pullarkat, Jeffrey S. Wasser, David Beenhouwer, Sarah N. Gibbs, Irina Yermilov, Michael S. Broder   +13 more
doaj   +1 more source

Neuroblast Migration and P2Y Receptor Mediated Calcium Signalling Depend on 9-O-Acetyl GD3 Ganglioside

ASN Neuro, 2012
Previous studies indicated that a ganglioside 9acGD3 (9-O-acetyl GD3) antibody [the J-Ab (Jones antibody)] reduces GCP (granule cell progenitor) migration in vitro and in vivo . We here investigated, using cerebellar explants of postnatal day (P) 6 mice,
Marcelo F Santiago, Eliana Scemes
doaj   +1 more source

Balloon purpura

International Journal of Pediatrics & Adolescent Medicine, 2021
Valsalva maneuvers have the potential to cause dermal capillary rupture manifesting as purpura and petechiae. We present a unique case of Valsalva purpura occurring in a 12-year-old girl after blowing up multiple balloons at a birthday party. Obtaining a
Victoria M. Madray, Kendall R. Liner, Loretta S. Davis   +2 more
doaj   +1 more source

Expansion Microscopy of Synaptic Contacts on the Mauthner Cells of Larval Zebrafish

Bio-Protocol
Because of its genetic tractability and amenability for live imaging, larval zebrafish (Danio rerio) have emerged as a model to study the cellular and synaptic properties underlying behavior.
Sundas Ijaz, Sandra Cárdenas-García, Alberto Pereda   +2 more
doaj   +1 more source

A novel method for estrous cycle staging using supervised object detection

NPP-Digital Psychiatry and Neuroscience
The estrous cycle regulates reproductive events and hormone changes in female mammals and is analogous to the menstrual cycle in humans. Monitoring this cycle is necessary as it serves as a biomarker for overall health and is crucial for interpreting ...
Benjamin Babaev, Saachi Goyal, Tushar Arora, Anita Autry, Rachel A. Ross   +4 more
doaj   +1 more source

The components of an electrical synapse as revealed by expansion microscopy of a single synaptic contact

eLife
Most nervous systems combine both transmitter-mediated and direct cell–cell communication, known as ‘chemical’ and ‘electrical’ synapses, respectively. Chemical synapses can be identified by their multiple structural components.
Sandra P Cárdenas-García, Sundas Ijaz, Alberto E Pereda   +2 more
doaj   +1 more source

Translational control of auditory imprinting and structural plasticity by eIF2α

eLife, 2016
The formation of imprinted memories during a critical period is crucial for vital behaviors, including filial attachment. Yet, little is known about the underlying molecular mechanisms.
Gervasio Batista, Jennifer Leigh Johnson, Elena Dominguez, Mauro Costa-Mattioli, Jose L Pena   +4 more
doaj   +1 more source

X-linked Christianson syndrome: heterozygous female Slc9a6 knockout mice develop mosaic neuropathological changes and related behavioral abnormalities

Disease Models & Mechanisms, 2016
Christianson syndrome (CS) is an X-linked neurodevelopmental and neurological disorder characterized in males by core symptoms that include non-verbal status, intellectual disability, epilepsy, truncal ataxia, postnatal microcephaly and hyperkinesis.
Jakub Sikora, Jennifer Leddy, Maria Gulinello, Steven U. Walkley   +3 more
doaj   +1 more source

Proteostasis and RNA Binding Proteins in Synaptic Plasticity and in the Pathogenesis of Neuropsychiatric Disorders

Neural Plasticity, 2016
Decades of research have demonstrated that rapid alterations in protein abundance are required for synaptic plasticity, a cellular correlate for learning and memory.
Matthew E. Klein, Hannah Monday, Bryen A. Jordan   +2 more
doaj   +1 more source

O secretário devoto: o De Praedicatore Verbi Dei e a retórica militante de Giovanni Botero

Revista de História
Giovanni Botero (Bene, 1544 – Turim, 1617) foi um erudito que colocou seus conhecimentos e suas habilidades retóricas à disposição da Igreja. Este ensaio investiga parte de sua atividade junto à diocese milanesa de Carlos Borromeu, na qual ele foi ...
Christian Purpura
doaj   +1 more source